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Int. J. Mol. Sci. 2010, 11(6), 2322-2335; doi:10.3390/ijms11062322

Temporal and Spatial Expression of Muc1 During Implantation in Sows

College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
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Received: 2 March 2010 / Revised: 4 April 2010 / Accepted: 21 May 2010 / Published: 27 May 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Recent evidence points to an important role for Muc1 in embryo implantation. In this study, Real-time PCR and immunohistochemistry were used to study mRNA and protein levels at, and between, the attachment sites of the endometrium of Day 13, 18 and 24 pregnant sows. The results indicate that Muc1 mRNA expression was higher between attachment sites than at attachment sites during implantation and this effect was significant on Day 13 (P < 0.01) and 24 (P < 0.01). Intense Muc1 immunostaining was observed in luminal epithelium and stroma and the staining between attachment sites was stronger than at attachment sites on Days 13 and 18. Collectively, these results suggest the crucial role of Muc1 in successful implantation and embryo survival.
Keywords: endometrium; expression; implantation; muc1; sows endometrium; expression; implantation; muc1; sows
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ren, Q.; Guan, S.; Fu, J.; Wang, A. Temporal and Spatial Expression of Muc1 During Implantation in Sows. Int. J. Mol. Sci. 2010, 11, 2322-2335.

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