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Int. J. Mol. Sci. 2010, 11(4), 1870-1877; doi:10.3390/ijms11041870

Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines

Received: 17 March 2010 / Revised: 31 March 2010 / Accepted: 1 April 2010 / Published: 26 April 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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A novel polyurethane was successfully synthesized by chain-extension of biodegradable poly (L-lactide) functionalized phosphatidylcholine (PC) with hexamethylene diisocyanate (HDI) as chain extender (PUR-PC). The molecular weights, glass transition temperature (Tg) increased significantly after the chain-extension. The hydrophilicity of PUR-PC was better than the one without PC, according to a water absorption test. Moreover, the number of adhesive platelets and anamorphic platelets on PUR-PC film were both less than those on PUR film. These preliminary results suggest that this novel polyurethane might be a better scaffold than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility. Besides, this study also provides a new method to prepare PC-modified biodegradable polyurethanes.
Keywords: polyurethanes; phosphatidylcholine; biodegradable; blood compatibility; polymer; surface polyurethanes; phosphatidylcholine; biodegradable; blood compatibility; polymer; surface
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cao, J.; Chen, N.; Chen, Y.; Luo, X. Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines. Int. J. Mol. Sci. 2010, 11, 1870-1877.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert