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Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines
College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China
State Key Lab of Polymer Materials and Engineering, Sichuan University, Chengdu 610065, China
* Author to whom correspondence should be addressed.
Received: 17 March 2010; in revised form: 31 March 2010 / Accepted: 1 April 2010 / Published: 26 April 2010
Abstract: A novel polyurethane was successfully synthesized by chain-extension of biodegradable poly (L-lactide) functionalized phosphatidylcholine (PC) with hexamethylene diisocyanate (HDI) as chain extender (PUR-PC). The molecular weights, glass transition temperature (Tg) increased significantly after the chain-extension. The hydrophilicity of PUR-PC was better than the one without PC, according to a water absorption test. Moreover, the number of adhesive platelets and anamorphic platelets on PUR-PC film were both less than those on PUR film. These preliminary results suggest that this novel polyurethane might be a better scaffold than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility. Besides, this study also provides a new method to prepare PC-modified biodegradable polyurethanes.
Keywords: polyurethanes; phosphatidylcholine; biodegradable; blood compatibility; polymer; surface
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MDPI and ACS Style
Cao, J.; Chen, N.; Chen, Y.; Luo, X. Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines. Int. J. Mol. Sci. 2010, 11, 1870-1877.
Cao J, Chen N, Chen Y, Luo X. Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines. International Journal of Molecular Sciences. 2010; 11(4):1870-1877.
Cao, Jun; Chen, Niancao; Chen, Yuanwei; Luo, Xianglin. 2010. "Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines." Int. J. Mol. Sci. 11, no. 4: 1870-1877.