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S. Louros Ana Filipa M. Cláudio Catarina M. S. S. Neves Mara G. Freire Isabel M. Marrucho Jérôme Pauly João A. P. Coutinho Aqueous biphasic systems (ABS) provide an alternative and efficient approach for the extraction, recovery and purification of biomolecules through their partitioning between two liquid aqueous phases. In this work, the ability of hydrophilic phosphonium-based ionic liquids (ILs) to form ABS with aqueous K3PO4 solutions was evaluated for the first time. Ternary phase diagrams, and respective tie-lines and tie-lines length, formed by distinct phosphonium-based ILs, water, and K3PO4 at 298 K, were measured and are reported. The studied phosphonium-based ILs have shown to be more effective in promoting ABS compared to the imidazolium-based counterparts with similar anions. Moreover, the extractive capability of such systems was assessed for distinct biomolecules (including amino acids, food colourants and alkaloids). Densities and viscosities of both aqueous phases, at the mass fraction compositions used for the biomolecules extraction, were also determined. The evaluated IL-based ABS have been shown to be prospective extraction media, particularly for hydrophobic biomolecules, with several advantages over conventional polymer-inorganic salt ABS. ionic liquids aqueous two-phase systems phase diagrams partition coefficients 2010-04-15T16:14:19+02:00 PScript5.dll Version 5.2.2 2010-04-15T16:15:53+02:00 2010-04-15T16:15:53+02:00 Acrobat Distiller 9.3.0 (Windows) ionic liquids; aqueous two-phase systems; phase diagrams; partition coefficients uuid:dec52ef7-0a88-4687-8a29-6d1691cb0c33 uuid:d84112fc-d189-4191-8e21-1e6c14b9fa64 False endstream endobj 40 0 obj <> endobj 58 0 obj <> endobj 59 0 obj <> endobj 60 0 obj <>/Filter/FlateDecode/ID[<8F0E892344D0C7D3D43BDB39BC16521D><335E3138536FA649BA0CF902F93BAFF7>]/Index[19 1 40 1 58 3]/Info 59 0 R/Length 30/Prev 116/Root 40 0 R/Size 61/Type/XRef/W[1 3 0]>>stream hbbdlfb`$@`w0 7X endstream endobj startxref 77851 %%EOF