Int. J. Mol. Sci. 2010, 11(3), 967-981; doi:10.3390/ijms11030967
Communication

Robust Uptake of Magnetic Nanoparticles (MNPs) by Central Nervous System (CNS) Microglia: Implications for Particle Uptake in Mixed Neural Cell Populations

Cellular and Neural Engineering Group, Institute for Science and Technology in Medicine, Keele University, Staffordshire, ST5 5BG, UK
* Author to whom correspondence should be addressed.
Received: 5 January 2010; in revised form: 2 March 2010 / Accepted: 4 March 2010 / Published: 8 March 2010
(This article belongs to the Special Issue Magnetic Nanoparticles)
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Abstract: Magnetic nanoparticles (MNPs) are important contrast agents used to monitor a range of neuropathological processes; microglial cells significantly contribute to MNP uptake in sites of pathology. Microglial activation occurs following most CNS pathologies but it is not known if such activation alters MNP uptake, intracellular processing and toxicity. We assessed these parameters in microglial cultures with and without experimental ‘activation’. Microglia showed rapid and extensive MNP uptake under basal conditions with no changes found following activation; significant microglial toxicity was observed at higher particle concentrations. Based on our findings, we suggest that avid MNP uptake by endogenous CNS microglia could significantly limit uptake by other cellular subtypes in mixed neural cell populations.
Keywords: magnetic; nanoparticles; microglia; toxicity; uptake

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MDPI and ACS Style

Pickard, M.R.; Chari, D.M. Robust Uptake of Magnetic Nanoparticles (MNPs) by Central Nervous System (CNS) Microglia: Implications for Particle Uptake in Mixed Neural Cell Populations. Int. J. Mol. Sci. 2010, 11, 967-981.

AMA Style

Pickard MR, Chari DM. Robust Uptake of Magnetic Nanoparticles (MNPs) by Central Nervous System (CNS) Microglia: Implications for Particle Uptake in Mixed Neural Cell Populations. International Journal of Molecular Sciences. 2010; 11(3):967-981.

Chicago/Turabian Style

Pickard, Mark R.; Chari, Divya M. 2010. "Robust Uptake of Magnetic Nanoparticles (MNPs) by Central Nervous System (CNS) Microglia: Implications for Particle Uptake in Mixed Neural Cell Populations." Int. J. Mol. Sci. 11, no. 3: 967-981.

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