Int. J. Mol. Sci. 2010, 11(3), 1155-1161; doi:10.3390/ijms11031155
Article

Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China

Hai Jiang 1,† email, Mao-Jun Zhang 1,† email, Rui-Chun Liu 2 email, Xin-Ying Tian 2 email, Yi-Xin Gu 1 email and Jian-Zhong Zhang 1,* email
1 National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, China 2 Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang 050051, China † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 January 2010; in revised form: 23 February 2010 / Accepted: 24 February 2010 / Published: 19 March 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Ganglioside mimicry by C. jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.
Keywords: Campylobacter jejuni; Guillain-Barré syndrome; lipo-oligosaccharides

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MDPI and ACS Style

Jiang, H.; Zhang, M.-J.; Liu, R.-C.; Tian, X.-Y.; Gu, Y.-X.; Zhang, J.-Z. Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China. Int. J. Mol. Sci. 2010, 11, 1155-1161.

AMA Style

Jiang H, Zhang M-J, Liu R-C, Tian X-Y, Gu Y-X, Zhang J-Z. Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China. International Journal of Molecular Sciences. 2010; 11(3):1155-1161.

Chicago/Turabian Style

Jiang, Hai; Zhang, Mao-Jun; Liu, Rui-Chun; Tian, Xin-Ying; Gu, Yi-Xin; Zhang, Jian-Zhong. 2010. "Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China." Int. J. Mol. Sci. 11, no. 3: 1155-1161.

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