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Int. J. Mol. Sci. 2010, 11(3), 1155-1161; doi:10.3390/ijms11031155

Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China

1
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, China
2
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang 050051, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 January 2010 / Revised: 23 February 2010 / Accepted: 24 February 2010 / Published: 19 March 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Ganglioside mimicry by C. jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.
Keywords: Campylobacter jejuni; Guillain-Barré syndrome; lipo-oligosaccharides Campylobacter jejuni; Guillain-Barré syndrome; lipo-oligosaccharides
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jiang, H.; Zhang, M.-J.; Liu, R.-C.; Tian, X.-Y.; Gu, Y.-X.; Zhang, J.-Z. Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China. Int. J. Mol. Sci. 2010, 11, 1155-1161.

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