Int. J. Mol. Sci. 2010, 11(3), 1141-1154; doi:10.3390/ijms11031141
Article

Proper Distance Metrics for Phylogenetic Analysis Using Complete Genomes without Sequence Alignment

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Received: 4 February 2010; Accepted: 3 March 2010 / Published: 18 March 2010
(This article belongs to the Special Issue Cladistic Analysis and Molecular Evolution)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A shortcoming of most correlation distance methods based on the composition vectors without alignment developed for phylogenetic analysis using complete genomes is that the “distances” are not proper distance metrics in the strict mathematical sense. In this paper we propose two new correlation-related distance metrics to replace the old one in our dynamical language approach. Four genome datasets are employed to evaluate the effects of this replacement from a biological point of view. We find that the two proper distance metrics yield trees with the same or similar topologies as/to those using the old “distance” and agree with the tree of life based on 16S rRNA in a majority of the basic branches. Hence the two proper correlation-related distance metrics proposed here improve our dynamical language approach for phylogenetic analysis.
Keywords: phylogenetic analysis; complete genome; composition vector; correlation-related distance metric
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MDPI and ACS Style

Yu, Z.-G.; Zhan, X.-W.; Han, G.-S.; Wang, R.W.; Anh, V.; Chu, K.H. Proper Distance Metrics for Phylogenetic Analysis Using Complete Genomes without Sequence Alignment. Int. J. Mol. Sci. 2010, 11, 1141-1154.

AMA Style

Yu Z-G, Zhan X-W, Han G-S, Wang RW, Anh V, Chu KH. Proper Distance Metrics for Phylogenetic Analysis Using Complete Genomes without Sequence Alignment. International Journal of Molecular Sciences. 2010; 11(3):1141-1154.

Chicago/Turabian Style

Yu, Zu-Guo; Zhan, Xiao-Wen; Han, Guo-Sheng; Wang, Roger W.; Anh, Vo; Chu, Ka Hou. 2010. "Proper Distance Metrics for Phylogenetic Analysis Using Complete Genomes without Sequence Alignment." Int. J. Mol. Sci. 11, no. 3: 1141-1154.


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