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Int. J. Mol. Sci. 2010, 11(3), 1057-1069; doi:10.3390/ijms11031057
Article

Potential Effects of Chrysin on MDA-MB-231 Cells

1,2
, 1
, 1
, 1
 and 1,*
1 Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia 2 School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
* Author to whom correspondence should be addressed.
Received: 21 January 2010 / Revised: 20 February 2010 / Accepted: 8 March 2010 / Published: 11 March 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 µM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
Keywords: chrysin; cell growth inhibition; lipid accumulation; apoptosis; PPAR mRNA expression; ER-negative breast cancer chrysin; cell growth inhibition; lipid accumulation; apoptosis; PPAR mRNA expression; ER-negative breast cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hong, T.B.; Rahumatullah, A.; Yogarajah, T.; Ahmad, M.; Yin, K.B. Potential Effects of Chrysin on MDA-MB-231 Cells. Int. J. Mol. Sci. 2010, 11, 1057-1069.

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