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• Hong, T
• Rahumatullah, A
• Yogarajah, T
• Ahmad, M
• Yin, K
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• Hong, T
• Rahumatullah, A
• Yogarajah, T
• Ahmad, M
• Yin, K
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• Hong, T
• Rahumatullah, A
• Yogarajah, T
• Ahmad, M
• Yin, K

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Int. J. Mol. Sci. 2010, 11(3), 1057-1069; doi:10.3390/ijms11031057

Article

Potential Effects of Chrysin on MDA-MB-231 Cells

Teh Ban Hong ^1,2 , Anizah Rahumatullah ¹ , Thaneswary Yogarajah ¹ , Maimunah Ahmad ¹  and Khoo Boon Yin ^1,*

¹ Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia ² School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia

* Author to whom correspondence should be addressed.

Received: 21 January 2010; in revised form: 20 February 2010 / Accepted: 8 March 2010 / Published: 11 March 2010

(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)

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Abstract: This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 µM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.

Keywords: chrysin; cell growth inhibition; lipid accumulation; apoptosis; PPAR mRNA expression; ER-negative breast cancer

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