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Potential Effects of Chrysin on MDA-MB-231 Cells
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
* Author to whom correspondence should be addressed.
Received: 21 January 2010; in revised form: 20 February 2010 / Accepted: 8 March 2010 / Published: 11 March 2010
Abstract: This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 µM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
Keywords: chrysin; cell growth inhibition; lipid accumulation; apoptosis; PPAR mRNA expression; ER-negative breast cancer
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Hong, T.B.; Rahumatullah, A.; Yogarajah, T.; Ahmad, M.; Yin, K.B. Potential Effects of Chrysin on MDA-MB-231 Cells. Int. J. Mol. Sci. 2010, 11, 1057-1069.
Hong TB, Rahumatullah A, Yogarajah T, Ahmad M, Yin KB. Potential Effects of Chrysin on MDA-MB-231 Cells. International Journal of Molecular Sciences. 2010; 11(3):1057-1069.
Hong, Teh Ban; Rahumatullah, Anizah; Yogarajah, Thaneswary; Ahmad, Maimunah; Yin, Khoo Boon. 2010. "Potential Effects of Chrysin on MDA-MB-231 Cells." Int. J. Mol. Sci. 11, no. 3: 1057-1069.