Int. J. Mol. Sci. 2010, 11(1), 1-13; doi:10.3390/ijms11010001

Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells

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Received: 28 October 2009; in revised form: 23 November 2009 / Accepted: 23 December 2009 / Published: 24 December 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces apoptosis in cancer cells and is not toxic to normal cells. We examined the cytotoxic and apoptotic effect of five chalcones in combination with TRAIL on prostate cancer cells. The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was determined using flow cytometry with annexin V-FITC. Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.
Keywords: chalcones; TRAIL (tumor necrosis factor-related apoptosis-inducing ligand); apoptosis; chemoprevention; prostate cancer
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MDPI and ACS Style

Szliszka, E.; Czuba, Z.P.; Mazur, B.; Sedek, L.; Paradysz, A.; Krol, W. Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells. Int. J. Mol. Sci. 2010, 11, 1-13.

AMA Style

Szliszka E, Czuba ZP, Mazur B, Sedek L, Paradysz A, Krol W. Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells. International Journal of Molecular Sciences. 2010; 11(1):1-13.

Chicago/Turabian Style

Szliszka, Ewelina; Czuba, Zenon P.; Mazur, Bogdan; Sedek, Lukasz; Paradysz, Andrzej; Krol, Wojciech. 2010. "Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells." Int. J. Mol. Sci. 11, no. 1: 1-13.

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