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Int. J. Mol. Sci. 2009, 10(9), 4187-4197; doi:10.3390/ijms10094187
Article

Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis

1,* , 2
 and 3,†
Received: 21 August 2009; Accepted: 21 September 2009 / Published: 24 September 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Estrogen is believed to be pre-initiator in the risk of breast cancer. The BRCA1 is a tumor suppressor gene associated with breast and ovarian cancer risk. This report describes functional analysis of two BRCA1 missense mutations (Asp67Glu and Thr1051Ser) observed in the familial breast/ovarian cancer patients in Thailand. Levels of luciferase activity of the two mutations were relatively lower than in the wild-type BRCA1. It is indicated that mutants may fail to promote the estrogen receptor dependent functions.It is presumed that estrogen and insulin/IGF-1 regulate c-Myc and cyclin D1 during breast cancer cell proliferation. It is also likely to affect ubiquitination mechanism. Since three affected cancer families carry the Asp67Glu mutation, it is believed that this type of mutation could have some effect on breast/ovarian cancer progression.
Keywords: BRCA1 missense mutation; estrogen; estrogen receptor signaling pathway; breast/ovarian carcinogenesis BRCA1 missense mutation; estrogen; estrogen receptor signaling pathway; breast/ovarian carcinogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pongsavee, M.; Patmasiriwat, P.; Saunders, G.F. Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis. Int. J. Mol. Sci. 2009, 10, 4187-4197.

AMA Style

Pongsavee M, Patmasiriwat P, Saunders GF. Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis. International Journal of Molecular Sciences. 2009; 10(9):4187-4197.

Chicago/Turabian Style

Pongsavee, Malinee; Patmasiriwat, Pimpicha; Saunders, Grady F. 2009. "Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis." Int. J. Mol. Sci. 10, no. 9: 4187-4197.


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