GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?

doi:10.3390/ijms10052066

This article is

freely available
re-usable

Int. J. Mol. Sci. 2009, 10(5), 2066-2083; doi:10.3390/ijms10052066

Review

GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?

Victor V. Marchenkov and Gennady V. Semisotnov *

Institute of Protein Research, Russian Academy of Sciences, 142290, Russian Federation, Pushchino, Moscow Region, Institutskaya street, 4, Russia

^* Author to whom correspondence should be addressed.

Received: 27 April 2009; in revised form: 8 May 2009 / Accepted: 11 May 2009 / Published: 12 May 2009

(This article belongs to the Special Issue Protein Folding)

Download PDF Full-Text [256 KB, uploaded 12 May 2009 09:10 CET]

Abstract: The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed.

Keywords: chaperones; GroEL/ES chaperonin system; protein folding; protein aggregation

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Marchenkov, V.V.; Semisotnov, G.V. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?. Int. J. Mol. Sci. 2009, 10, 2066-2083.

AMA Style

Marchenkov V.V., Semisotnov G.V. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?. International Journal of Molecular Sciences. 2009; 10(5):2066-2083.

Chicago/Turabian Style

Marchenkov, Victor V.; Semisotnov, Gennady V. 2009. "GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?." Int. J. Mol. Sci. 10, no. 5: 2066-2083.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert