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Int. J. Mol. Sci. 2009, 10(5), 2066-2083; doi:10.3390/ijms10052066
Review

GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?

 and *
Received: 27 April 2009; in revised form: 8 May 2009 / Accepted: 11 May 2009 / Published: 12 May 2009
(This article belongs to the Special Issue Protein Folding)
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Abstract: The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed.
Keywords: chaperones; GroEL/ES chaperonin system; protein folding; protein aggregation chaperones; GroEL/ES chaperonin system; protein folding; protein aggregation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Marchenkov, V.V.; Semisotnov, G.V. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity? Int. J. Mol. Sci. 2009, 10, 2066-2083.

AMA Style

Marchenkov VV, Semisotnov GV. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity? International Journal of Molecular Sciences. 2009; 10(5):2066-2083.

Chicago/Turabian Style

Marchenkov, Victor V.; Semisotnov, Gennady V. 2009. "GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?" Int. J. Mol. Sci. 10, no. 5: 2066-2083.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert