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Int. J. Mol. Sci. 2009, 10(5), 2066-2083; doi:10.3390/ijms10052066
Review

GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?

 and
*
Institute of Protein Research, Russian Academy of Sciences, 142290, Russian Federation, Pushchino, Moscow Region, Institutskaya street, 4, Russia
* Author to whom correspondence should be addressed.
Received: 27 April 2009 / Revised: 8 May 2009 / Accepted: 11 May 2009 / Published: 12 May 2009
(This article belongs to the Special Issue Protein Folding 2009)
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Abstract

The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed.
Keywords: chaperones; GroEL/ES chaperonin system; protein folding; protein aggregation chaperones; GroEL/ES chaperonin system; protein folding; protein aggregation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Marchenkov, V.V.; Semisotnov, G.V. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity? Int. J. Mol. Sci. 2009, 10, 2066-2083.

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