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GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
Institute of Protein Research, Russian Academy of Sciences, 142290, Russian Federation, Pushchino, Moscow Region, Institutskaya street, 4, Russia
* Author to whom correspondence should be addressed.
Received: 27 April 2009; in revised form: 8 May 2009 / Accepted: 11 May 2009 / Published: 12 May 2009
Abstract: The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed.
Keywords: chaperones; GroEL/ES chaperonin system; protein folding; protein aggregation
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Marchenkov, V.V.; Semisotnov, G.V. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity? Int. J. Mol. Sci. 2009, 10, 2066-2083.
Marchenkov VV, Semisotnov GV. GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity? International Journal of Molecular Sciences. 2009; 10(5):2066-2083.
Marchenkov, Victor V.; Semisotnov, Gennady V. 2009. "GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?" Int. J. Mol. Sci. 10, no. 5: 2066-2083.