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Int. J. Mol. Sci. 2009, 10(5), 1967-1977; doi:10.3390/ijms10051967
Article

Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs

1
, 2
 and 1, 3,*
Received: 13 April 2009; in revised form: 23 April 2009 / Accepted: 24 April 2009 / Published: 28 April 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents.
Keywords: GH-deficient Mini rats; dorsal skin; hair cycle; microarray analysis GH-deficient Mini rats; dorsal skin; hair cycle; microarray analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Umeda-Ikawa, A.; Shimokawa, I.; Doi, K. Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs. Int. J. Mol. Sci. 2009, 10, 1967-1977.

AMA Style

Umeda-Ikawa A, Shimokawa I, Doi K. Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs. International Journal of Molecular Sciences. 2009; 10(5):1967-1977.

Chicago/Turabian Style

Umeda-Ikawa, Aya; Shimokawa, Isao; Doi, Kunio. 2009. "Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs." Int. J. Mol. Sci. 10, no. 5: 1967-1977.


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