Next Article in Journal
Current Mathematical Methods Used in QSAR/QSPR Studies
Previous Article in Journal
Self-Assembly of Optical Molecules with Supramolecular Concepts
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2009, 10(5), 1967-1977; doi:10.3390/ijms10051967

Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs

1
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan
2
Department of Respiratory and Digestive Medicine, Division of Experimental Medicine, Pathology, and Gerontology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan
3
Nippon Institute for Biological Science, 9-2221-1, Shin-Machi, Ome, Tokyo 198-0024, Japan
*
Author to whom correspondence should be addressed.
Received: 13 April 2009 / Revised: 23 April 2009 / Accepted: 24 April 2009 / Published: 28 April 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [1290 KB, uploaded 19 June 2014]   |  

Abstract

Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents.
Keywords: GH-deficient Mini rats; dorsal skin; hair cycle; microarray analysis GH-deficient Mini rats; dorsal skin; hair cycle; microarray analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Umeda-Ikawa, A.; Shimokawa, I.; Doi, K. Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs. Int. J. Mol. Sci. 2009, 10, 1967-1977.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top