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Int. J. Mol. Sci. 2009, 10(5), 1967-1977; doi:10.3390/ijms10051967

Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs

1
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan
2
Department of Respiratory and Digestive Medicine, Division of Experimental Medicine, Pathology, and Gerontology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan
3
Nippon Institute for Biological Science, 9-2221-1, Shin-Machi, Ome, Tokyo 198-0024, Japan
*
Author to whom correspondence should be addressed.
Received: 13 April 2009 / Revised: 23 April 2009 / Accepted: 24 April 2009 / Published: 28 April 2009
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents. View Full-Text
Keywords: GH-deficient Mini rats; dorsal skin; hair cycle; microarray analysis GH-deficient Mini rats; dorsal skin; hair cycle; microarray analysis
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Umeda-Ikawa, A.; Shimokawa, I.; Doi, K. Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs. Int. J. Mol. Sci. 2009, 10, 1967-1977.

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