Int. J. Mol. Sci. 2009, 10(4), 1525-1537; doi:10.3390/ijms10041525
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Pseudo-Replication of [GADV]-Proteins and Origin of Life

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Received: 16 January 2009; in revised form: 30 March 2009 / Accepted: 1 April 2009 / Published: 2 April 2009
(This article belongs to the Special Issue Origin of Life)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The RNA world hypothesis on the origin of life is generally considered as the key to solve the “chicken and egg dilemma” concerning the evolution of genes and proteins as observed in the modern organisms. This hypothesis, however, contains several serious weak points. We have a counterproposal called [GADV]-protein world hypothesis, abbreviated as GADV hypothesis, in which we have suggested that life originated from a [GADV]-protein world, which comprised proteins composed of four amino acids: Gly [G], Ala [A], Asp [D], and Val [V]. A new concept “pseudo-replication” is crucial for the description of the emergence of life. The new hypothesis not only plausibly explains how life originated from the initial chaotic protein world, but also how genes, genetic code, and proteins co-evolved.
Keywords: GADV hypothesis; pseudo-replication; [GADV]-protein world; origin of life
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MDPI and ACS Style

Ikehara, K. Pseudo-Replication of [GADV]-Proteins and Origin of Life. Int. J. Mol. Sci. 2009, 10, 1525-1537.

AMA Style

Ikehara K. Pseudo-Replication of [GADV]-Proteins and Origin of Life. International Journal of Molecular Sciences. 2009; 10(4):1525-1537.

Chicago/Turabian Style

Ikehara, Kenji. 2009. "Pseudo-Replication of [GADV]-Proteins and Origin of Life." Int. J. Mol. Sci. 10, no. 4: 1525-1537.

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