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Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research
INSERM U884, Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier 2280 Rue de la Piscine, BP 53, Grenoble Cedex 9, France
Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23,12618 Tallinn, Estonia
* Author to whom correspondence should be addressed.
Received: 3 February 2009; in revised form: 7 March 2009 / Accepted: 12 March 2009 / Published: 13 March 2009
Abstract: We live in times of paradigmatic changes for the biological sciences. Reductionism, that for the last six decades has been the philosophical basis of biochemistry and molecular biology, is being displaced by Systems Biology, which favors the study of integrated systems. Historically, Systems Biology - defined as the higher level analysis of complex biological systems - was pioneered by Claude Bernard in physiology, Norbert Wiener with the development of cybernetics, and Erwin Schrödinger in his thermodynamic approach to the living. Systems Biology applies methods inspired by cybernetics, network analysis, and non-equilibrium dynamics of open systems. These developments follow very precisely the dialectical principles of development from thesis to antithesis to synthesis discovered by Hegel. Systems Biology opens new perspectives for studies of the integrated processes of energy metabolism in different cells. These integrated systems acquire new, system-level properties due to interaction of cellular components, such as metabolic compartmentation, channeling and functional coupling mechanisms, which are central for regulation of the energy fluxes. State of the art of these studies in the new area of Molecular System Bioenergetics is analyzed.
Keywords: Systems Biology; Molecular Systems Bioenergetics; cellular energy metabolism; regulation; compartmentation; energy transfer systems
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Saks, V.; Monge, C.; Guzun, R. Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. Int. J. Mol. Sci. 2009, 10, 1161-1192.
Saks V, Monge C, Guzun R. Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. International Journal of Molecular Sciences. 2009; 10(3):1161-1192.
Saks, Valdur; Monge, Claire; Guzun, Rita. 2009. "Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research." Int. J. Mol. Sci. 10, no. 3: 1161-1192.