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Int. J. Mol. Sci. 2009, 10(3), 1161-1192; doi:10.3390/ijms10031161
Review

Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research

1, 2,* , 1
 and 1
Received: 3 February 2009; in revised form: 7 March 2009 / Accepted: 12 March 2009 / Published: 13 March 2009
(This article belongs to the Special Issue Molecular System Bioenergetics)
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Abstract: We live in times of paradigmatic changes for the biological sciences. Reductionism, that for the last six decades has been the philosophical basis of biochemistry and molecular biology, is being displaced by Systems Biology, which favors the study of integrated systems. Historically, Systems Biology - defined as the higher level analysis of complex biological systems - was pioneered by Claude Bernard in physiology, Norbert Wiener with the development of cybernetics, and Erwin Schrödinger in his thermodynamic approach to the living. Systems Biology applies methods inspired by cybernetics, network analysis, and non-equilibrium dynamics of open systems. These developments follow very precisely the dialectical principles of development from thesis to antithesis to synthesis discovered by Hegel. Systems Biology opens new perspectives for studies of the integrated processes of energy metabolism in different cells. These integrated systems acquire new, system-level properties due to interaction of cellular components, such as metabolic compartmentation, channeling and functional coupling mechanisms, which are central for regulation of the energy fluxes. State of the art of these studies in the new area of Molecular System Bioenergetics is analyzed.
Keywords: Systems Biology; Molecular Systems Bioenergetics; cellular energy metabolism; regulation; compartmentation; energy transfer systems Systems Biology; Molecular Systems Bioenergetics; cellular energy metabolism; regulation; compartmentation; energy transfer systems
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Saks, V.; Monge, C.; Guzun, R. Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. Int. J. Mol. Sci. 2009, 10, 1161-1192.

AMA Style

Saks V, Monge C, Guzun R. Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. International Journal of Molecular Sciences. 2009; 10(3):1161-1192.

Chicago/Turabian Style

Saks, Valdur; Monge, Claire; Guzun, Rita. 2009. "Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research." Int. J. Mol. Sci. 10, no. 3: 1161-1192.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert