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Int. J. Mol. Sci. 2009, 10(2), 646-655; doi:10.3390/ijms10020646

Effect of Nanoparticles on Protein Folding and Fibrillogenesis

1, 2
National Laboratory of Biomacromoleules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China
Author to whom correspondence should be addressed.
Received: 18 January 2009 / Revised: 1 February 2009 / Accepted: 10 February 2009 / Published: 20 February 2009
(This article belongs to the Special Issue Protein Folding 2009)
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The large surface area and small size of nanoparticles provide properties and applications that are distinct from those of bulk materials. The ability of nanoparticles to influence protein folding and aggregation is interesting, not only because of the potential beneficial applications, but also the potential risks to human health and the environment. This makes it essential that we understand the effect of nanoparticles on fundamental biological process, like protein folding. Here, we review studies that have examined the effect of nanoparticles on protein folding and aggregation, providing insight both into the mechanisms of these processes and how they may be controlled. View Full-Text
Keywords: Nanoparticles; protein folding; fibrillogenesis; amyloid Nanoparticles; protein folding; fibrillogenesis; amyloid

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fei, L.; Perrett, S. Effect of Nanoparticles on Protein Folding and Fibrillogenesis. Int. J. Mol. Sci. 2009, 10, 646-655.

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