Abstract: Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.
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Edmondson, D.A.; Barrios, C.S.; Brasel, T.L.; Straus, D.C.; Kurup, V.P.; Fink, J.N. Immune Response among Patients Exposed to Molds. Int. J. Mol. Sci. 2009, 10, 5471-5484.
Edmondson DA, Barrios CS, Brasel TL, Straus DC, Kurup VP, Fink JN. Immune Response among Patients Exposed to Molds. International Journal of Molecular Sciences. 2009; 10(12):5471-5484.
Edmondson, David A.; Barrios, Christy S.; Brasel, Trevor L.; Straus, David C.; Kurup, Viswanath P.; Fink, Jordan N. 2009. "Immune Response among Patients Exposed to Molds." Int. J. Mol. Sci. 10, no. 12: 5471-5484.