Cell Culture on MEMS Platforms: A Review

doi:10.3390/ijms10125411

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Int. J. Mol. Sci. 2009, 10(12), 5411-5441; doi:10.3390/ijms10125411

Review

Cell Culture on MEMS Platforms: A Review

Ming Ni ¹ , Wen Hao Tong ^1,2 , Deepak Choudhury ^1,2 , Nur Aida Abdul Rahim ³, Ciprian Iliescu ¹^,* and Hanry Yu ^1,2,3,4,5

¹ Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore ² NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), #05-01, 28 Medical Drive, Singapore 117456, Singapore ³ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9 #03-03, 2 Medical Drive, Singapore 117597, Singapore ⁴ NUS Tissue-Engineering Programme, DSO Labs, National University of Singapore, Singapore 117597, Singapore ⁵ Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

* Author to whom correspondence should be addressed.

Received: 13 November 2009; in revised form: 13 December 2009 / Accepted: 16 December 2009 / Published: 18 December 2009

(This article belongs to the Special Issue Biocompatibility of Materials)

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Abstract: Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bioincompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bioincompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.

Keywords: cell culture; MEMS platforms; biocompatibility; biomaterials

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MDPI and ACS Style

Ni, M.; Tong, W.H.; Choudhury, D.; Rahim, N.A.A.; Iliescu, C.; Yu, H. Cell Culture on MEMS Platforms: A Review. Int. J. Mol. Sci. 2009, 10, 5411-5441.

AMA Style

Ni M., Tong W.H., Choudhury D., Rahim N.A.A., Iliescu C., Yu H. Cell Culture on MEMS Platforms: A Review. International Journal of Molecular Sciences. 2009; 10(12):5411-5441.

Chicago/Turabian Style

Ni, Ming; Tong, Wen Hao; Choudhury, Deepak; Rahim, Nur Aida Abdul; Iliescu, Ciprian; Yu, Hanry. 2009. "Cell Culture on MEMS Platforms: A Review." Int. J. Mol. Sci. 10, no. 12: 5411-5441.

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