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Cell Culture on MEMS Platforms: A Review
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore
NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), #05-01, 28 Medical Drive, Singapore 117456, Singapore
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9 #03-03, 2 Medical Drive, Singapore 117597, Singapore
NUS Tissue-Engineering Programme, DSO Labs, National University of Singapore, Singapore 117597, Singapore
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
* Author to whom correspondence should be addressed.
Received: 13 November 2009; in revised form: 13 December 2009 / Accepted: 16 December 2009 / Published: 18 December 2009
Abstract: Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bioincompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bioincompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.
Keywords: cell culture; MEMS platforms; biocompatibility; biomaterials
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MDPI and ACS Style
Ni, M.; Tong, W.H.; Choudhury, D.; Rahim, N.A.A.; Iliescu, C.; Yu, H. Cell Culture on MEMS Platforms: A Review. Int. J. Mol. Sci. 2009, 10, 5411-5441.
Ni M, Tong WH, Choudhury D, Rahim NAA, Iliescu C, Yu H. Cell Culture on MEMS Platforms: A Review. International Journal of Molecular Sciences. 2009; 10(12):5411-5441.
Ni, Ming; Tong, Wen Hao; Choudhury, Deepak; Rahim, Nur Aida Abdul; Iliescu, Ciprian; Yu, Hanry. 2009. "Cell Culture on MEMS Platforms: A Review." Int. J. Mol. Sci. 10, no. 12: 5411-5441.