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Int. J. Mol. Sci. 2009, 10(12), 5411-5441; doi:10.3390/ijms10125411

Cell Culture on MEMS Platforms: A Review

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Received: 13 November 2009 / Revised: 13 December 2009 / Accepted: 16 December 2009 / Published: 18 December 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
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Abstract: Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bioincompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bioincompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.
Keywords: cell culture; MEMS platforms; biocompatibility; biomaterials cell culture; MEMS platforms; biocompatibility; biomaterials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ni, M.; Tong, W.H.; Choudhury, D.; Rahim, N.A.A.; Iliescu, C.; Yu, H. Cell Culture on MEMS Platforms: A Review. Int. J. Mol. Sci. 2009, 10, 5411-5441.

AMA Style

Ni M, Tong WH, Choudhury D, Rahim NAA, Iliescu C, Yu H. Cell Culture on MEMS Platforms: A Review. International Journal of Molecular Sciences. 2009; 10(12):5411-5441.

Chicago/Turabian Style

Ni, Ming; Tong, Wen Hao; Choudhury, Deepak; Rahim, Nur Aida Abdul; Iliescu, Ciprian; Yu, Hanry. 2009. "Cell Culture on MEMS Platforms: A Review." Int. J. Mol. Sci. 10, no. 12: 5411-5441.

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