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Int. J. Mol. Sci. 2009, 10(12), 5411-5441; doi:10.3390/ijms10125411

Cell Culture on MEMS Platforms: A Review

3, 1,*  and 1,2,3,4,5
1 Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore 2 NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), #05-01, 28 Medical Drive, Singapore 117456, Singapore 3 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9 #03-03, 2 Medical Drive, Singapore 117597, Singapore 4 NUS Tissue-Engineering Programme, DSO Labs, National University of Singapore, Singapore 117597, Singapore 5 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
* Author to whom correspondence should be addressed.
Received: 13 November 2009 / Revised: 13 December 2009 / Accepted: 16 December 2009 / Published: 18 December 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
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Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bioincompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bioincompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.
Keywords: cell culture; MEMS platforms; biocompatibility; biomaterials cell culture; MEMS platforms; biocompatibility; biomaterials
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ni, M.; Tong, W.H.; Choudhury, D.; Rahim, N.A.A.; Iliescu, C.; Yu, H. Cell Culture on MEMS Platforms: A Review. Int. J. Mol. Sci. 2009, 10, 5411-5441.

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