Int. J. Mol. Sci. 2009, 10(1), 50-61; doi:10.3390/ijms10010050
Article

Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1

1 Departamento de Microbiologia e Imunologia, Instituto de Veterinária da Universidade Federal Rural do Rio de Janeiro, CEP 23890.000, Rio de Janeiro, RJ, Brasil 2 Departamento de Bromatologia e Química do Instituto Adolfo Lutz, CEP. 01246-902, São Paulo, Brasil 3 Instituto de Pesquisa Energéticas e Nucleares (IPEN / CNEN - SP), CEP 05508-000, São Paulo, SP, Brasil 4 Departamento de Microbiologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, CEP: 05508-900, São Paulo, SP, Brasil 5 Instituto de Zootecnia, Nova Odessa, 13460-000, SP, Brasil
* Author to whom correspondence should be addressed.
Received: 2 April 2008; in revised form: 12 December 2008 / Accepted: 17 December 2008 / Published: 27 December 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B1 (FB1). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB1. Prolonged exposure to FB1 caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB1. Animals receiving a single dose of FB1 presented variations in Sa and So levels and in the Sa/So ratio.
Keywords: Fumonisin B1; sphingolipids; biomarkers; Wistar rats; prolonged effect; single dose

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MDPI and ACS Style

Direito, G.M.; Almeida, A.P.; Aquino, S.; Alves dos Reis, T.; Rodrigues Pozzi, C.; Corrêa, B. Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1. Int. J. Mol. Sci. 2009, 10, 50-61.

AMA Style

Direito GM, Almeida AP, Aquino S, Alves dos Reis T, Rodrigues Pozzi C, Corrêa B. Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1. International Journal of Molecular Sciences. 2009; 10(1):50-61.

Chicago/Turabian Style

Direito, Glória M.; Almeida, Adriana P.; Aquino, Simone; Alves dos Reis, Tatiana; Rodrigues Pozzi, Claudia; Corrêa, Benedito. 2009. "Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1." Int. J. Mol. Sci. 10, no. 1: 50-61.

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