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Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1
Departamento de Microbiologia e Imunologia, Instituto de Veterinária da Universidade Federal Rural do Rio de Janeiro, CEP 23890.000, Rio de Janeiro, RJ, Brasil
Departamento de Bromatologia e Química do Instituto Adolfo Lutz, CEP. 01246-902, São Paulo, Brasil
Instituto de Pesquisa Energéticas e Nucleares (IPEN / CNEN - SP), CEP 05508-000, São Paulo, SP, Brasil
Departamento de Microbiologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, CEP: 05508-900, São Paulo, SP, Brasil
Instituto de Zootecnia, Nova Odessa, 13460-000, SP, Brasil
* Author to whom correspondence should be addressed.
Received: 2 April 2008; in revised form: 12 December 2008 / Accepted: 17 December 2008 / Published: 27 December 2008
Abstract: The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B1 (FB1). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB1. Prolonged exposure to FB1 caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB1. Animals receiving a single dose of FB1 presented variations in Sa and So levels and in the Sa/So ratio.
Keywords: Fumonisin B1; sphingolipids; biomarkers; Wistar rats; prolonged effect; single dose
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Direito, G.M.; Almeida, A.P.; Aquino, S.; Alves dos Reis, T.; Rodrigues Pozzi, C.; Corrêa, B. Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1. Int. J. Mol. Sci. 2009, 10, 50-61.
Direito GM, Almeida AP, Aquino S, Alves dos Reis T, Rodrigues Pozzi C, Corrêa B. Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1. International Journal of Molecular Sciences. 2009; 10(1):50-61.
Direito, Glória M.; Almeida, Adriana P.; Aquino, Simone; Alves dos Reis, Tatiana; Rodrigues Pozzi, Claudia; Corrêa, Benedito. 2009. "Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B1." Int. J. Mol. Sci. 10, no. 1: 50-61.