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• Direito, GM.
• Almeida, AP.
• Aquino, S
• Alves dos Reis, T
• Rodrigues Pozzi, C
• Corrêa, B
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• Direito, GM.
• Almeida, AP.
• Aquino, S
• Alves dos Reis, T
• Rodrigues Pozzi, C
• Corrêa, B
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• Direito, GM.
• Almeida, AP.
• Aquino, S
• Alves dos Reis, T
• Rodrigues Pozzi, C
• Corrêa, B

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Int. J. Mol. Sci. 2009, 10(1), 50-61; doi:10.3390/ijms10010050

Article

Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B₁

Glória M. Direito¹ , Adriana P. Almeida² , Simone Aquino³ , Tatiana Alves dos Reis⁴ , Claudia Rodrigues Pozzi⁵  and Benedito Corrêa^4,*

¹ Departamento de Microbiologia e Imunologia, Instituto de Veterinária da Universidade Federal Rural do Rio de Janeiro, CEP 23890.000, Rio de Janeiro, RJ, Brasil ² Departamento de Bromatologia e Química do Instituto Adolfo Lutz, CEP. 01246-902, São Paulo, Brasil ³ Instituto de Pesquisa Energéticas e Nucleares (IPEN / CNEN - SP), CEP 05508-000, São Paulo, SP, Brasil ⁴ Departamento de Microbiologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, CEP: 05508-900, São Paulo, SP, Brasil ⁵ Instituto de Zootecnia, Nova Odessa, 13460-000, SP, Brasil

* Author to whom correspondence should be addressed.

Received: 2 April 2008; in revised form: 12 December 2008 / Accepted: 17 December 2008 / Published: 27 December 2008

(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)

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Abstract: The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B₁ (FB₁). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB₁. Prolonged exposure to FB₁ caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB₁. Animals receiving a single dose of FB₁ presented variations in Sa and So levels and in the Sa/So ratio.

Keywords: Fumonisin B1; sphingolipids; biomarkers; Wistar rats; prolonged effect; single dose

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