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Molecules 2004, 9(7), 535-540; doi:10.3390/90700535
Article

Formation of the Imidazolinone Ring Under Mild Conditions in the Presence of Sodium Hydride

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Received: 11 December 2003 / Revised: 15 September 2004 / Accepted: 19 September 2004 / Published: 30 June 2004
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Abstract

Substituted imidazolinones containing heterocyclic carboxylic acids as substituents and possessing herbicidal properties were synthesized by cyclization of 2-amino-2,3-dimethylbutyramide with heterocyclic ethyl dicarboxylates under mild conditions. The use of NaH as base leads to a significant increase in the reaction rate and allows the preparation of the target compounds in high yields.
Keywords: Imidazolinones; herbicides; cyclization; sodium hydride Imidazolinones; herbicides; cyclization; sodium hydride
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Vasiliev, A.N.; Lopez, A.F.; Fernandez, J.D.; Mocchi, A.J. Formation of the Imidazolinone Ring Under Mild Conditions in the Presence of Sodium Hydride. Molecules 2004, 9, 535-540.

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