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Molecules 2004, 9(7), 535-540; doi:10.3390/90700535

Formation of the Imidazolinone Ring Under Mild Conditions in the Presence of Sodium Hydride

* , ,  and
Center for Chemical Research and Technologies, Cordoba Faculty, National Technological University, C.C. 17, Suc. 16, Cordoba 5016, Argentina
* Author to whom correspondence should be addressed.
Received: 11 December 2003 / Revised: 15 September 2004 / Accepted: 19 September 2004 / Published: 30 June 2004
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Substituted imidazolinones containing heterocyclic carboxylic acids as substituents and possessing herbicidal properties were synthesized by cyclization of 2-amino-2,3-dimethylbutyramide with heterocyclic ethyl dicarboxylates under mild conditions. The use of NaH as base leads to a significant increase in the reaction rate and allows the preparation of the target compounds in high yields.
Keywords: Imidazolinones; herbicides; cyclization; sodium hydride Imidazolinones; herbicides; cyclization; sodium hydride
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vasiliev, A.N.; Lopez, A.F.; Fernandez, J.D.; Mocchi, A.J. Formation of the Imidazolinone Ring Under Mild Conditions in the Presence of Sodium Hydride. Molecules 2004, 9, 535-540.

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