Next Article in Journal / Special Issue
Self-Terminating, Oxidative Radical Cyclizations
Previous Article in Journal / Special Issue
Preparation of Novel Selenopenams by Intramolecular Homolytic Substitution
Molecules 2004, 9(6), 472-479; doi:10.3390/90600472
Article

Toward Pyridine-Fused Selenium-Containing Antioxidants

 and *
School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia
* Author to whom correspondence should be addressed.
Received: 17 February 2004 / Accepted: 21 February 2004 / Published: 31 May 2004
(This article belongs to the Special Issue RACI 2003 symposium)
View Full-Text   |   Download PDF [228 KB, uploaded 18 June 2014]   |  

Abstract

Photolysis of the thiohydroximate ester derivative 21 of 2-carboethoxy-2-(2- (benzylseleno)pyridin-3-yl)tridecylcarboxylic acid (20) affords 2-dodecyl-2- carboethoxy-2,3-dihydroselenolo[2,3-b]pyridine (22) in 89% yield in a process presumably involving intramolecular homolytic substitution by a tertiary alkyl radical at selenium with loss of a benzyl radical. Work toward extending this methodology to the preparation of pyridine-fused selenium analogues of antioxidants is described.
Keywords: Free radical; homolytic substitution; selenium; antioxidants. Free radical; homolytic substitution; selenium; antioxidants.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Fenner, T.; Schiesser, C.H. Toward Pyridine-Fused Selenium-Containing Antioxidants. Molecules 2004, 9, 472-479.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert