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Molecules 2004, 9(4), 204-212; doi:10.3390/90400204
Article

Synthesis of Some New 4,5-Substituted-4H-1,2,4-triazole-3-thiol Derivatives

* ,  and
Department of Chemistry, Faculty of Science, Fırat University, 23119, Elazığ, Turkey
* Author to whom correspondence should be addressed.
Received: 11 July 2003 / Revised: 9 February 2004 / Accepted: 2 February 2004 / Published: 31 March 2004
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Abstract

In this study appropriate hydrazide compounds, furan-2-carboxylic acidhydrazide (1) and phenylacetic acid hydrazide (2) were converted into 1,4-substitutedthiosemicarbazides 4a-e and 5a-e and 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The 1,4-substituted thiosemicarbazides were then converted into5-(furan-2-yl or benzyl)-4-(aryl)-4H-1,2,4-triazole-3-thiols 8a-e and 9a-e. In addition, theazomethines 11a-d and 12a-d were prepared from the corresponding arylaldehydes and the4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The structures of allthe synthesized compounds were confirmed by elemental analyses, IR, 1H-NMR and13 C-NMR spectra.
Keywords: 4H-1; 2; 4-triazole-3-thiols; azomethines; thiosemicarbazides. 4H-1; 2; 4-triazole-3-thiols; azomethines; thiosemicarbazides.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Koparır, M.; Cansız, A.; Demirdağ, A. Synthesis of Some New 4,5-Substituted-4H-1,2,4-triazole-3-thiol Derivatives. Molecules 2004, 9, 204-212.

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