Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

doi:10.3390/91100978

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Molecules 2004, 9(11), 978-987; doi:10.3390/91100978

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Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

Jie Shi¹, Mei-Yu Geng^1,* and Chang-Xiao Liu³

¹ Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, 5 Yushan Road, Qingdao 266003, P. R. China ² Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, P. R. China ³ Tianjin Drug Institute, 38 Anshanxi Road, Tianjin, P. R. China

* Author to whom correspondence should be addressed.

Received: 7 July 2004 / Accepted: 1 August 2004 / Published: 30 November 2004

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Abstract: The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.

Keywords: Cocktail approach; enzymes; drug safety evaluation.

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MDPI and ACS Style

Shi, J.; Geng, M.-Y.; Liu, C.-X. Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach. Molecules 2004, 9, 978-987.

AMA Style

Shi J, Geng M-Y, Liu C-X. Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach. Molecules. 2004; 9(11):978-987.

Chicago/Turabian Style

Shi, Jie; Geng, Mei-Yu; Liu, Chang-Xiao. 2004. "Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach." Molecules 9, no. 11: 978-987.

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