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Molecules 2004, 9(11), 978-987; doi:10.3390/91100978
Article

Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

1, 1,*  and 3
1 Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, 5 Yushan Road, Qingdao 266003, P. R. China 2 Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, P. R. China 3 Tianjin Drug Institute, 38 Anshanxi Road, Tianjin, P. R. China
* Author to whom correspondence should be addressed.
Received: 7 July 2004 / Accepted: 1 August 2004 / Published: 30 November 2004
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Abstract

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.
Keywords: Cocktail approach; enzymes; drug safety evaluation. Cocktail approach; enzymes; drug safety evaluation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shi, J.; Geng, M.-Y.; Liu, C.-X. Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach. Molecules 2004, 9, 978-987.

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