Next Article in Journal
Special Issue on Flexible Molecular Descriptors
Previous Article in Journal
Preparation of Poly(oxybutyleneoxymaleoyl) Catalyzed by a Proton Exchanged Montmorillonite Clay
Article Menu

Export Article

Open AccessArticle
Molecules 2004, 9(11), 978-987; doi:10.3390/91100978

Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

1
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, 5 Yushan Road, Qingdao 266003, P. R. China
2
Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, P. R. China
3
Tianjin Drug Institute, 38 Anshanxi Road, Tianjin, P. R. China
*
Author to whom correspondence should be addressed.
Received: 7 July 2004 / Accepted: 1 August 2004 / Published: 30 November 2004
View Full-Text   |   Download PDF [255 KB, uploaded 18 June 2014]   |  

Abstract

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs. View Full-Text
Keywords: Cocktail approach; enzymes; drug safety evaluation. Cocktail approach; enzymes; drug safety evaluation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shi, J.; Geng, M.-Y.; Liu, C.-X. Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach. Molecules 2004, 9, 978-987.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top