Molecules 2004, 9(11), 978-987; doi:10.3390/91100978
Article

Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

1, 1,* email and 3
Received: 7 July 2004; Accepted: 1 August 2004 / Published: 30 November 2004
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.
Keywords: Cocktail approach; enzymes; drug safety evaluation.
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MDPI and ACS Style

Shi, J.; Geng, M.-Y.; Liu, C.-X. Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach. Molecules 2004, 9, 978-987.

AMA Style

Shi J, Geng M-Y, Liu C-X. Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach. Molecules. 2004; 9(11):978-987.

Chicago/Turabian Style

Shi, Jie; Geng, Mei-Yu; Liu, Chang-Xiao. 2004. "Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach." Molecules 9, no. 11: 978-987.

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