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Molecules 2003, 8(9), 678-686; doi:10.3390/80900678

Synthesis of 2-(4-Methoxyphenyl)pyrrolo[2,1-d]pyrido[2,3-c]-[1,5]-thiazepin-3(2H)-one

College of Pharmacy, Catholic University of Daegu, Hayang, 712-702, Korea
Received: 7 March 2003 / Revised: 24 July 2003 / Accepted: 3 August 2003 / Published: 17 August 2003
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2-(4-Methoxyphenyl)pyrrolo[2,1-d]pyrido[2,3-c][1,5]thiazepin-3(2H)-one, a key intermediate in the synthesis of pyrrolopyridothiazepine derivatives, was synthesized from bis(4H-pyrrolo-3-pyridyl)disulfide and α-bromo-(4-methoxyphenyl) acetic acid ethyl ester in order to develop a novel calcium channel antagonist.
Keywords: Calcium channel antagonist; Thiation; Pyrrolopyridothiazepine; Intramolecular cyclization Calcium channel antagonist; Thiation; Pyrrolopyridothiazepine; Intramolecular cyclization
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Ma, E. Synthesis of 2-(4-Methoxyphenyl)pyrrolo[2,1-d]pyrido[2,3-c]-[1,5]-thiazepin-3(2H)-one. Molecules 2003, 8, 678-686.

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