Next Article in Journal / Special Issue
Solid-Phase Synthesis of Methyl N-(pyrimidin-2-yl)glycinate
Previous Article in Journal / Special Issue
Special Issue: Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry
Article Menu

Export Article

Open AccessArticle
Molecules 2003, 8(6), 460-466; https://doi.org/10.3390/80600460

Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles

Chemistry Department, Moscow State University, Moscow 119899, Russia
*
Author to whom correspondence should be addressed.
Received: 13 May 2003 / Revised: 17 June 2003 / Accepted: 17 June 2003 / Published: 30 June 2003
View Full-Text   |   Download PDF [129 KB, uploaded 18 June 2014]   |  

Abstract

5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II. These salts II readily react with ammonia and aliphatic amines leading to the products of pyridine ring opening - previously unknown 1-amino-2-nitro-4-(oxazole-2-yl)butadienes-1,3. Reaction of salts II with water lead to hydrolytic cleavage of the oxazole fragment. View Full-Text
Keywords: 5-Nitro-2-pyridone; oxazolo[3; 2-a]pyridine; butadiene; nitrodiene; aminodiene; oxazolyldiene 5-Nitro-2-pyridone; oxazolo[3; 2-a]pyridine; butadiene; nitrodiene; aminodiene; oxazolyldiene
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Bush, A.A.; Babaev, E.V. Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles. Molecules 2003, 8, 460-466.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top