Molecules 2003, 8(6), 460-466; doi:10.3390/80600460
Article

Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles

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Received: 13 May 2003; in revised form: 17 June 2003 / Accepted: 17 June 2003 / Published: 30 June 2003
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II. These salts II readily react with ammonia and aliphatic amines leading to the products of pyridine ring opening - previously unknown 1-amino-2-nitro-4-(oxazole-2-yl)butadienes-1,3. Reaction of salts II with water lead to hydrolytic cleavage of the oxazole fragment.
Keywords: 5-Nitro-2-pyridone; oxazolo[3; 2-a]pyridine; butadiene; nitrodiene; aminodiene; oxazolyldiene
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MDPI and ACS Style

Bush, A.A.; Babaev, E.V. Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles. Molecules 2003, 8, 460-466.

AMA Style

Bush AA, Babaev EV. Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles. Molecules. 2003; 8(6):460-466.

Chicago/Turabian Style

Bush, Alexander A.; Babaev, Eugene V. 2003. "Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles." Molecules 8, no. 6: 460-466.


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