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Molecules 2003, 8(1), 86-91; doi:10.3390/80100086
Article

Atomic Force Microscope Imaging of the Aggregation of Mouse Immunoglobulin G Molecules

* , , , , ,  and
Received: 1 January 2003; Published: 31 January 2003
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Abstract: Mouse immunoglobulin G (Ig G1 and the mixture of Ig G1 and Ig G2) deposited on mica were imaged with an atomic force microscope at room temperature and ambient pressure. At a concentration around 1.0mg/L, the molecules were well dispersed. 2~3 days after sample preparation, both Ig G1 and the mixture could self- assemble into different shapes and further form some types of local-ordered toroidal aggregations (monotoroidal, intercrossed toroidal, concentric toroidal, etc.). The number of monomers was not identical in the different toroidal aggregations but in a same circle, the shapes of polymer self-assembled by several monomolecules were found to be almost the same. There was difference between the aggregation behavior of Ig G1 and the mixture. The mechanism of Ig G molecule aggregation was ascribed to the “Y” shape and loops structure of Ig G molecule.
Keywords: Mouse immunoglobulin G; self-assembly; aggregation; atomic force microscope Mouse immunoglobulin G; self-assembly; aggregation; atomic force microscope
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cai, J.; Chen, Y.; Xu, Q.; Chen, Y.; Zhao, T.; Wang, X.; Xia, K. Atomic Force Microscope Imaging of the Aggregation of Mouse Immunoglobulin G Molecules. Molecules 2003, 8, 86-91.

AMA Style

Cai J, Chen Y, Xu Q, Chen Y, Zhao T, Wang X, Xia K. Atomic Force Microscope Imaging of the Aggregation of Mouse Immunoglobulin G Molecules. Molecules. 2003; 8(1):86-91.

Chicago/Turabian Style

Cai, Jiye; Chen, Yao; Xu, Qingcai; Chen, Yong; Zhao, Tao; Wang, Xiaoyan; Xia, Ke. 2003. "Atomic Force Microscope Imaging of the Aggregation of Mouse Immunoglobulin G Molecules." Molecules 8, no. 1: 86-91.



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