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Molecules 2002, 7(7), 507-510; doi:10.3390/70700507
Article

Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane

1,* , 1, 2, 2 and 2
1 Département de Chimie, Université Abdelmalek Essaâdi, Faculté des Sciences, B.P 2121, Tétouan, Morocco 2 Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, E- 28040, Spain
* Author to whom correspondence should be addressed.
Received: 24 September 2001 / Revised: 3 July 2002 / Accepted: 8 July 2002 / Published: 31 July 2002
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Abstract

The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride.
Keywords: [4+2] Cycloaddition; Diels-Alder adduct; dimethyl 2; 4-diphenylquinazoline dicarboxylate [4+2] Cycloaddition; Diels-Alder adduct; dimethyl 2; 4-diphenylquinazoline dicarboxylate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chioua, R.; Benabdelouahab, F.; Chioua, M.; Martínez-Alvarez, R.; Fernández, A.H. Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane. Molecules 2002, 7, 507-510.

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