Molecules 2002, 7(2), 129-134; doi:10.3390/70200129

An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone

1,* email, 2email, 2 and 2
Received: 23 May 2001; in revised form: 15 January 2002 / Accepted: 31 January 2002 / Published: 28 February 2002
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: (-)-Carvone (3) has been efficiently transformed into (-)-3β-hydroxycarvone (1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound 1 involves regioselective and stereoselective α-hydroxylation of carvone via the trimethylsilyl-dienyl-ether derivative.
Keywords: Carvone; 3β-hydroxycarvone; silyl enol ether; stereoselective synthesis
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MDPI and ACS Style

Dos Santos, R.B.; Brocksom, T.J.; Zanotto, P.R.; Brocksom, U. An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone. Molecules 2002, 7, 129-134.

AMA Style

Dos Santos RB, Brocksom TJ, Zanotto PR, Brocksom U. An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone. Molecules. 2002; 7(2):129-134.

Chicago/Turabian Style

Dos Santos, Reginaldo B.; Brocksom, Timothy J.; Zanotto, Paulo R.; Brocksom, Ursula. 2002. "An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone." Molecules 7, no. 2: 129-134.

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