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Molecules 2002, 7(2), 129-134; doi:10.3390/70200129

An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone

Departamento de Química, Universidade Federal do Espírito Santo, 29060-900, Vitória, ES, Brazil
Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905, São Carlos, SP, Brazil
Author to whom correspondence should be addressed.
Received: 23 May 2001 / Revised: 15 January 2002 / Accepted: 31 January 2002 / Published: 28 February 2002
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(-)-Carvone (3) has been efficiently transformed into (-)-3β-hydroxycarvone (1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound 1 involves regioselective and stereoselective α-hydroxylation of carvone via the trimethylsilyl-dienyl-ether derivative. View Full-Text
Keywords: Carvone; 3β-hydroxycarvone; silyl enol ether; stereoselective synthesis Carvone; 3β-hydroxycarvone; silyl enol ether; stereoselective synthesis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dos Santos, R.B.; Brocksom, T.J.; Zanotto, P.R.; Brocksom, U. An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone. Molecules 2002, 7, 129-134.

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