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Molecules, Volume 6, Issue 9 (September 2001) – 7 articles , Pages 716-795

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Research

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68 KiB  
Article
Synthesis of Camalexin
by M. Dzurilla, P. Kutschy, J. Zaletova, M. Ruzinsky and V. Kovacik
Molecules 2001, 6(9), 716-720; https://doi.org/10.3390/60900716 - 31 Aug 2001
Cited by 14 | Viewed by 7732
Abstract
In this paper we describe a new method for the synthesis of camalexin (1) based on the reaction of 1-(tert-butoxycarbonyl)indole-3-carboxaldehyde with methyl Lcysteinate hydrochloride, followed by oxidation and decarboxylation. Compounds 1, and intermediates 5-7 were identified by elemental analysis, 1H NMR, 13 [...] Read more.
In this paper we describe a new method for the synthesis of camalexin (1) based on the reaction of 1-(tert-butoxycarbonyl)indole-3-carboxaldehyde with methyl Lcysteinate hydrochloride, followed by oxidation and decarboxylation. Compounds 1, and intermediates 5-7 were identified by elemental analysis, 1H NMR, 13C NMR and mass spectroscopy. Full article
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34 KiB  
Article
Chemistry of Pyrones, Part 5: New Crown Ether and Podand Derivatives of 3,5-Bis(bromomethyl)-2,6-diphenyl-4H-pyran-4-one
by Aziz Shahrisa and Alireza Banaei
Molecules 2001, 6(9), 721-727; https://doi.org/10.3390/60900721 - 31 Aug 2001
Cited by 11 | Viewed by 7710
Abstract
New podand and crown ether derivatives of 3,5-disubstituted 4H-pyran-4-one (8-11) were prepared by the nucleophilic substitution reaction of 3,5-bis(bromomethyl)-2,6-diphenyl-4H-pyran-4-one with o-nitrophenol, 8-hydroxyquinoline, 2-hydroxymethyl pyridine and triethyleneglycol, respectively. The yield of 3,5-bis[(2-formylphenoxy) methyl]-2,6-diphenyl-4H-pyran-4-one has been improved by modification of our previous method using NaOH [...] Read more.
New podand and crown ether derivatives of 3,5-disubstituted 4H-pyran-4-one (8-11) were prepared by the nucleophilic substitution reaction of 3,5-bis(bromomethyl)-2,6-diphenyl-4H-pyran-4-one with o-nitrophenol, 8-hydroxyquinoline, 2-hydroxymethyl pyridine and triethyleneglycol, respectively. The yield of 3,5-bis[(2-formylphenoxy) methyl]-2,6-diphenyl-4H-pyran-4-one has been improved by modification of our previous method using NaOH instead of Et3N. Full article
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46 KiB  
Article
Synthesis of Furan Derivatives Condensed with Carbohydrates
by Mauro V. De Almeida, Mireille Le Hyaric, Leonardo J. A. Siqueira, Luciana D. Pinto, Marcelo S. Valle and Wendel A. Alves
Molecules 2001, 6(9), 728-735; https://doi.org/10.3390/60900728 - 31 Aug 2001
Cited by 6 | Viewed by 11388
Abstract
Eight new furan derivatives have been prepared and characterized. These compounds were obtained by condensation of aminosugar and aminocyclitol intermediates with furan derivatives. Full article
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38 KiB  
Article
Niobium Pentachloride Catalysed Ring Opening of Epoxides
by Mauricio Gomes Constantino, Valdemar Lacerda, Jr. and Valquiria Aragão
Molecules 2001, 6(9), 770-776; https://doi.org/10.3390/60900770 - 31 Aug 2001
Cited by 34 | Viewed by 8648
Abstract
Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl5 for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both [...] Read more.
Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl5 for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested. Full article
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113 KiB  
Article
Crystal and molecular structure of cis-Dichlorobis(triphenylphosphite) Platinum(II)
by Seyyed Javad Sabounchei and Ali Naghipour
Molecules 2001, 6(9), 777-783; https://doi.org/10.3390/60900777 - 31 Aug 2001
Cited by 7 | Viewed by 7396
Abstract
The single crystal structure of cis-dichlorobis(triphenyphosphite) platinum(II), [PtCl2(P(OPh)3)2] has been determined. This complex crystallises in the orthorhombic space group, P212121 with cell constant, a=10.4135(13), b=14.0635(16), c=23.505(3) Ǻ and v=3448.3(7) Ǻ 3. [...] Read more.
The single crystal structure of cis-dichlorobis(triphenyphosphite) platinum(II), [PtCl2(P(OPh)3)2] has been determined. This complex crystallises in the orthorhombic space group, P212121 with cell constant, a=10.4135(13), b=14.0635(16), c=23.505(3) Ǻ and v=3448.3(7) Ǻ 3. The Pt-Cl1 and Pt-Cl2 distances are 2.3390(10) Ǻ and 2.3256 Ǻ, which are longer than Pt-P1 and Pt-P2 with 2.1985(12) Ǻ and 2.1998(10) Ǻ respectively. These data together with bond angles suggest a distorted square planar geometry for this complex with two chlorine ligands in a cis configuration. Full article
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63 KiB  
Article
Biologically Active 1-Arylpiperazines. Synthesis of New N-(4-Aryl-1-piperazinyl)alkyl Derivatives of Quinazolidin-4(3H)-one, 2,3-Dihydrophthalazine-1,4-dione and 1,2-Dihydropyridazine-3,6-dione as Potential Serotonin Receptor Ligands
by Piotr Kowalski, Teresa Kowalska, Maria J. Mokrosz, Andrzej J. Bojarski and Sijka Charakchieva-Minol
Molecules 2001, 6(9), 784-795; https://doi.org/10.3390/60900784 - 31 Aug 2001
Cited by 17 | Viewed by 8585
Abstract
The synthesis of a series of new n-propyl and n-butyl chain containing 1-arylpiperazine derivatives of quinazolidin-4(3H)-one (7) 2-phenyl-2,3-dihydrophthalazine-1,4-dione (8) and 1-phenyl-1,2-dihydropyridazine-3,6-dione (9) as potential serotonin receptor ligands is described. Full article
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Review

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302 KiB  
Review
Tyrian Purple: 6,6’-Dibromoindigo and Related Compounds
by Christopher J. Cooksey
Molecules 2001, 6(9), 736-769; https://doi.org/10.3390/60900736 - 31 Aug 2001
Cited by 212 | Viewed by 27087
Abstract
The genesis of the purple dye from shellfish, its composition, origin, intermediates, analysis and synthesis of the components, 6,6’-dibromoindigo, 6-bromoindigo and 6,6’-dibromoindirubin are reviewed. Full article
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