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Niobium Pentachloride Catalysed Ring Opening of Epoxides
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, 14040-901 – Ribeirão Preto – SP, Brazil
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Received: 11 June 2001; in revised form: 24 August 2001 / Accepted: 24 August 2001 / Published: 31 August 2001
Abstract: Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl5 for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested.
Keywords: Niobium pentachloride; Epoxides; 1; 2-Diols; Chlorohydrins
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Constantino, M.G.; Lacerda, V., Jr.; Aragão, V. Niobium Pentachloride Catalysed Ring Opening of Epoxides. Molecules 2001, 6, 770-776.
Constantino MG, Lacerda V, Jr, Aragão V. Niobium Pentachloride Catalysed Ring Opening of Epoxides. Molecules. 2001; 6(9):770-776.
Constantino, Mauricio G.; Lacerda, Valdemar, Jr.; Aragão, Valquiria. 2001. "Niobium Pentachloride Catalysed Ring Opening of Epoxides." Molecules 6, no. 9: 770-776.