Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2

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Molecules 2001, 6(8), 647-654; doi:10.3390/60800647

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Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH₂CH₂COOSn(n-Bu) ₂]₄O₂

Dai-shu Zuo ¹, Tao Jiang ¹^,* , Hua-shi Guan ¹, Kui-qi Wang ¹, Xin Qi ¹ and Zhan Shi ²

¹ Marine Drug and Food Institute, Ocean University of Qingdao, Qingdao, China ² Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, China

* Author to whom correspondence should be addressed.

Received: 19 March 2001; in revised form: 20 March 2001 / Accepted: 2 May 2001 / Published: 31 July 2001

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Abstract: Dibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH₂)_nCOOSn(n-Bu)₂]₄O₂ (I, n=2; II, n=1) which were characterized by IR and ¹H-NMR. The crystal structure of complex I shows that the molecular is a dimer, in which two [(5-Fu)-1-CH₂CH₂COOSn(n-Bu)₂]₂O units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-Fu and bridging oxygen. These complexes have potential anti-tumour activity: in vitro tests showed that complexes I and II exhibit high cytotoxicity against OVCAR-3 and PC-14.

Keywords: Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity

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MDPI and ACS Style

Zuo, D.-S.; Jiang, T.; Guan, H.-S.; Wang, K.-Q.; Qi, X.; Shi, Z. Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH₂CH₂COOSn(n-Bu) ₂]₄O₂. Molecules 2001, 6, 647-654.

AMA Style

Zuo D.-S., Jiang T., Guan H.-S., Wang K.-Q., Qi X., Shi Z. Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH₂CH₂COOSn(n-Bu) ₂]₄O₂. Molecules. 2001; 6(8):647-654.

Chicago/Turabian Style

Zuo, Dai-shu; Jiang, Tao; Guan, Hua-shi; Wang, Kui-qi; Qi, Xin; Shi, Zhan. 2001. "Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH₂CH₂COOSn(n-Bu) ₂]₄O₂." Molecules 6, no. 8: 647-654.

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