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Retraction published on 31 July 2003, see Molecules 2003, 8(7), 520.

Molecules 2001, 6(8), 647-654; doi:10.3390/60800647
Article

Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2

1, 1,* , 1, 1, 1 and 2
1 Marine Drug and Food Institute, Ocean University of Qingdao, Qingdao, China 2 Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, China
* Author to whom correspondence should be addressed.
Received: 19 March 2001 / Revised: 20 March 2001 / Accepted: 2 May 2001 / Published: 31 July 2001
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Abstract

Dibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH2)nCOOSn(n-Bu)2]4O2 (I, n=2; II, n=1) which were characterized by IR and 1H-NMR. The crystal structure of complex I shows that the molecular is a dimer, in which two [(5-Fu)-1-CH2CH2COOSn(n-Bu)2]2O units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-Fu and bridging oxygen. These complexes have potential anti-tumour activity: in vitro tests showed that complexes I and II exhibit high cytotoxicity against OVCAR-3 and PC-14.
Keywords: Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zuo, D.-S.; Jiang, T.; Guan, H.-S.; Wang, K.-Q.; Qi, X.; Shi, Z. Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2. Molecules 2001, 6, 647-654.

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