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Molecules 2001, 6(8), 647-654; doi:10.3390/60800647
Article

Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2

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Received: 19 March 2001; in revised form: 20 March 2001 / Accepted: 2 May 2001 / Published: 31 July 2001
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Abstract: Dibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH2)nCOOSn(n-Bu)2]4O2 (I, n=2; II, n=1) which were characterized by IR and 1H-NMR. The crystal structure of complex I shows that the molecular is a dimer, in which two [(5-Fu)-1-CH2CH2COOSn(n-Bu)2]2O units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-Fu and bridging oxygen. These complexes have potential anti-tumour activity: in vitro tests showed that complexes I and II exhibit high cytotoxicity against OVCAR-3 and PC-14.
Keywords: Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zuo, D.-S.; Jiang, T.; Guan, H.-S.; Wang, K.-Q.; Qi, X.; Shi, Z. Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2. Molecules 2001, 6, 647-654.

AMA Style

Zuo D-S, Jiang T, Guan H-S, Wang K-Q, Qi X, Shi Z. Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2. Molecules. 2001; 6(8):647-654.

Chicago/Turabian Style

Zuo, Dai-shu; Jiang, Tao; Guan, Hua-shi; Wang, Kui-qi; Qi, Xin; Shi, Zhan. 2001. "Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2." Molecules 6, no. 8: 647-654.


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