Next Article in Journal
Use of Cyclic Allylic Bromides in the Zinc–Mediated Aqueous Barbier–Grignard Reaction
Previous Article in Journal
Electrochemical Study of Bromide in the Presence of 1,3-Indandione. Application to the Electrochemical Synthesis of Bromo Derivatives of 1,3-Indandione
Article Menu

Export Article

Retraction published on 31 July 2003, see Molecules 2003, 8(7), 520.

Open AccessArticle
Molecules 2001, 6(8), 647-654; doi:10.3390/60800647

Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2

1
Marine Drug and Food Institute, Ocean University of Qingdao, Qingdao, China
2
Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, China
*
Author to whom correspondence should be addressed.
Received: 19 March 2001 / Revised: 20 March 2001 / Accepted: 2 May 2001 / Published: 31 July 2001
View Full-Text   |   Download PDF [101 KB, uploaded 18 June 2014]   |  

Abstract

Dibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH2)nCOOSn(n-Bu)2]4O2 (I, n=2; II, n=1) which were characterized by IR and 1H-NMR. The crystal structure of complex I shows that the molecular is a dimer, in which two [(5-Fu)-1-CH2CH2COOSn(n-Bu)2]2O units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-Fu and bridging oxygen. These complexes have potential anti-tumour activity: in vitro tests showed that complexes I and II exhibit high cytotoxicity against OVCAR-3 and PC-14.
Keywords: Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity Organotin complex; 5-Fu; synthesis; crystal structure; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zuo, D.-S.; Jiang, T.; Guan, H.-S.; Wang, K.-Q.; Qi, X.; Shi, Z. Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2. Molecules 2001, 6, 647-654.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top