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Molecules 2001, 6(7), 621-638; doi:10.3390/60700621
Article

Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position

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Received: 19 February 2001; in revised form: 4 June 2001 / Accepted: 7 June 2001 / Published: 30 June 2001
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Abstract: Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene S,S-acetals (1a), S,Nacetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously unreported 1-[6-(p-tolyl)-pyridazin-3-yl]pyrazolo[3,4-d]pyrimidines (8, 9, 13-20) and 7-[6-( p-tolyl) pyridazin-3-yl]2-arylpyrazolo[3,4-d]1,2,4-triazolo[5,1-f]pyrimidines (10-12) which are expected to possess considerable chemical and pharmacological activities.
Keywords: ο-Aminonitriles; ketene acetals; pyrazolopyrimidines ο-Aminonitriles; ketene acetals; pyrazolopyrimidines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Afaleq, E.I.; Abubshait, S.A. Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position. Molecules 2001, 6, 621-638.

AMA Style

Al-Afaleq EI, Abubshait SA. Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position. Molecules. 2001; 6(7):621-638.

Chicago/Turabian Style

Al-Afaleq, Eljazi I.; Abubshait, Samar A. 2001. "Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position." Molecules 6, no. 7: 621-638.


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