Next Article in Journal
Synthesis of D-Homo Analogs of Neurosteroids
Previous Article in Journal
Synthesis of Aziridinosteroids
Molecules 2000, 5(3), 445-446; doi:10.3390/50300445

3,3-Dimethylacylthioureas: "S", "-S", "U" or "W" Conformation?

1, 2 and 3
1 Facultad de Química, Universidad de La Habana, Cuba 2 Instituto Superior de Ciencias y Tecnologías Nucleares, Cuba 3 Depto. de Química Orgánica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires, Argentina
* Author to whom correspondence should be addressed.
Published: 22 March 2000
Download PDF [15 KB, uploaded 18 June 2014]


We report a study of 3,3-dimethyl substituted acylthioureas. X ray data and quantum mechanical calculations demonstrated that the "S" conformation is the most stable both for the acylthioureas and the corresponding anions. The high regioselectivity towards S-alkylation is explained on the basis of the localization of the HOMO mainly over the sulfur atom.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Sosa, M.; Piris, M.; Burton, G. 3,3-Dimethylacylthioureas: "S", "-S", "U" or "W" Conformation? Molecules 2000, 5, 445-446.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert