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Abstract

Electrosynthesis of 3-Nitrophenotiazine. Nitration in Non-Aqueous Solutions

Dpto de Química y Física, Universidad Nacional de Río Cuarto. Agencia Postal N: 3, 5800, Río Cuarto, Argentina
*
Author to whom correspondence should be addressed.
Molecules 2000, 5(3), 374-375; https://doi.org/10.3390/50300374
Published: 22 March 2000

Abstract

:
The nitration of Phenothiazine (PHEN) in acetonitrile (ACN) in the presence of excess NaNO2 has been studied in detail. First, the electrochemical behavior of the reactants was investigated by cyclic voltammetry to determine the electrolysis conditions. Controlled- potential electrolysis was used for the electrosynthesis.

Introduction

Although the nitration of organic compounds is an area in expansion since the beginning of the century principles, its interest has not diminished. In this way, new nitration methods that outline new challenges for the interpretation of the mechanisms have appeared. The principal interest resides in that the nitrated products are fundamental source of diverse synthetic products [1,2,3]. The traditional nitra- tion methods, which use aggressive mixtures of nitric and sulfuric acid, are being left, due to the high cost of the effluents treatment [4]. The electrochemical methods are an excellent way to produce the nitration intermediates [5]. Besides, it constitutes an interesting alternative procedure from the mecha- nistic point of view.

Experimental

An EG & PAR model 273 potensiostat-galvanostat was used for cyclic voltammetry (CV) and con- trolled-potential electrolysis (CPE) measurements, using a conventional three-compartment Pyrex cell, stirring with a Teflon paddle for the EPC. The working electrodes were Pt wires of area 0.235 cm2 for CV, and Pt electrodes of larger area (ca.16 cm2) for CPE. The counter-electrode was a stainless steel foil of large area. All the potentials were referred to a saturated calomel electrode (SCE) and were cor- rected for IR drop by positive feedback techniques.
The disappearance of the reagent and the consequent apparition of the nitrated product were fol- lowed by HPLC analyses. 3-Nitrophenotiazine (3-NO2PHEN) was thermally synthesized as described in the literature [6].

Results and Discussion

CV studies shows that the oxidation of PHEN to proceed in two reversible one-electron steps, giving the radical cation PHEN+• and the dication PHEN++, respectively, peak I (EpI = 0.58 V) and peak II (EpII = 1.00 V). Since for the electrosynthesis we are only interested in the generation of the PHEN+•, the CV were registered until 0.8 V. The peak current IpI shows a linear dependence on v1/2 in the range of sweep rates used (i.e. 0.01 to 0.3 V s-1) and EpI as well as ΔEpI give a constant value on v. This is the expected behavior for a fast diffusion controlled process. At the same potential, the ion NO2- is oxi- dized to NO2. Nevertheless, CV studies showed that the nitrated product is formed by the reaction between the FEN++ (formed by desproportionation of PHEN+• and the NO2- ion
CPE was performed at E = 0.5 V. Several samples were taken to different times of electrolysis, following by HPLC the increase of the peak of the product ( τ = 23 min). A yield greater than 90% of 3- NO2PHEN was obtained under optimized conditions. A reaction mechanism is proposed.

Acknowledgements

Financial support from CONICET, CONICOR, FONCYT and the Secretaría de Ciencia y Técnica de la Universidad Nacional de Rio Cuarto is gratefully acknowledged. Patricia Perlo thanks CONICOR for a research fellowship.

References and Notes

  1. Olah, G.A. Chemistry of Energetic Materials; Academic Press: New York, 1991; Cap. 7. [Google Scholar]
  2. Ridd, J.H. Chem. Soc. Rev. 1991, 20, 149. [CrossRef]
  3. Eberson, L.; Radner, F. Acc. Chem. Res. 1987, 20, 53. [CrossRef]
  4. Smith; Musson, A.; DeBoos, G. A. Chem . Commun 1996, 469.
  5. Laurent, A.; Laurent, E.; Locher, P. Electrochim. Acta 1975, 20.
  6. Shine, H.J.; Silber, J.J.; Bussey, R.J.; Okuyama, T. J.Org Chem 1972, 37, 2697.

Share and Cite

MDPI and ACS Style

Perlo, P.A.; Cortona, M.N.; Silber, J.J.; Sereno, L.E. Electrosynthesis of 3-Nitrophenotiazine. Nitration in Non-Aqueous Solutions. Molecules 2000, 5, 374-375. https://doi.org/10.3390/50300374

AMA Style

Perlo PA, Cortona MN, Silber JJ, Sereno LE. Electrosynthesis of 3-Nitrophenotiazine. Nitration in Non-Aqueous Solutions. Molecules. 2000; 5(3):374-375. https://doi.org/10.3390/50300374

Chicago/Turabian Style

Perlo, P. A., M. N. Cortona, J. J. Silber, and L. E. Sereno. 2000. "Electrosynthesis of 3-Nitrophenotiazine. Nitration in Non-Aqueous Solutions" Molecules 5, no. 3: 374-375. https://doi.org/10.3390/50300374

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