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17O NMR Spectra of α,β-Unsaturated Carbonyl Compounds RCH=CHCOX: the Influence of Group X on the δ(17O) Value of the Carbonyl Oxygen and on the Shielding Effect of Group R
Molecules 1999, 4(11), 329-332; doi:10.3390/41100329


Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria, 3052, Australia
Received: 13 August 1999 / Accepted: 20 October 1999 / Published: 25 October 1999
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A method to synthesize desmethylclozapine, 3, is reported. The procedure afforded the target compound in 69% yield. A by-product, isolated from the reaction mixture in 11% yield, proved to be the title compound, 4.
Keywords: desmethylclozapine; amidine formation; titanium tetrachloride desmethylclozapine; amidine formation; titanium tetrachloride
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Capuano, B. 8-Chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazino]-5H-dibenzo[b,e][1,4]diazepine. Molecules 1999, 4, 329-332.

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