An Efficient, Self-Protecting Route to Dimethyl 4-Amino-4-[2-(methoxycarbonyl)ethyl]-heptanedioate HCl

doi:10.3390/40100013

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Molecules 1999, 4(1), 13-15; doi:10.3390/40100013

Article

An Efficient, Self-Protecting Route to Dimethyl 4-Amino-4-[2-(methoxycarbonyl)ethyl]-heptanedioate HCl

Sally Henrie and Rita S.K. Majerle *

Department of Chemistry and Biochemistry, South Dakota State University, Box 2202, Brookings, South Dakota 57007, USA

* Author to whom correspondence should be addressed.

Received: 10 September 1998 / Accepted: 5 January 1999 / Published: 9 February 1999

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Abstract: A method to reduce the nitro moiety in dimethyl 4-nitro-4-[1-[2(methoxycarbonyl)ethyl]]heptanedioate using a T-1 Raney nickel catalyst in an acidic environment is reported. The method avoids facile lactam formation.

Keywords: Nitro reduction; lactam formation; amine salt

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MDPI and ACS Style

Henrie, S.; Majerle, R.S.K. An Efficient, Self-Protecting Route to Dimethyl 4-Amino-4-[2-(methoxycarbonyl)ethyl]-heptanedioate HCl. Molecules 1999, 4, 13-15.

AMA Style

Henrie S., Majerle R.S.K. An Efficient, Self-Protecting Route to Dimethyl 4-Amino-4-[2-(methoxycarbonyl)ethyl]-heptanedioate HCl. Molecules. 1999; 4(1):13-15.

Chicago/Turabian Style

Henrie, Sally; Majerle, Rita S.K. 1999. "An Efficient, Self-Protecting Route to Dimethyl 4-Amino-4-[2-(methoxycarbonyl)ethyl]-heptanedioate HCl." Molecules 4, no. 1: 13-15.

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