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Second Annual Conference on Strategies and Techniques for Identification of Novel Bioactive Compounds. October 8-9, 1998 Zurich, Switzerland
Molecules 1998, 3(6), 149-158; doi:10.3390/30600149
Article

Synthesis and Reactions of New 4-Oxo-4H-benzopyran-3-carboxaldehydes Containing Hydroxy Groups or 2-Oxopyran Cycles

1,* , 1, 1, 2 and 3
1 Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, SK-84215 Bratislava, Slovak Republic 2 Slovak Academy of Sciences, 842 38 Bratislava, Slovak Republic 3 Department of Chemistry, Faculty of Education,Ain Shams University, Roxy, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 27 January 1998 / Accepted: 14 April 1998 / Published: 15 May 1998
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Abstract

The synthesis of eight hydroxy- and 2-oxopyranochromone-3-carboxaldehydes 3, 5 and their reactions with 2-hydroxyaniline, 2,4-dinitrophenylhydrazine and 2-benzothiazolylhydrazine were investigated. Products were confirmed by IR, NMR spectral and elemental analysis data. The semi-empirical AM1 quantum-chemical method has been used to study optimal geometries and heats of formation of synthesized 3-formylchromones.
Keywords: 3-Formylchromones; Vilsmeier - Haack reaction; 2-oxobenzopyrane; imines; enamines; AM1 calculations 3-Formylchromones; Vilsmeier - Haack reaction; 2-oxobenzopyrane; imines; enamines; AM1 calculations
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Lacova, M.; Loos, D.; Furdik, M.; Matulova, M.; El-Shaaer, H.M. Synthesis and Reactions of New 4-Oxo-4H-benzopyran-3-carboxaldehydes Containing Hydroxy Groups or 2-Oxopyran Cycles. Molecules 1998, 3, 149-158.

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