Next Article in Journal
Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold
Previous Article in Journal
Microwave (MW), Ultrasound (US) and Combined Synergic MW-US Strategies for Rapid Functionalization of Pharmaceutical Use Phenols
Article Menu

Export Article

Open AccessArticle
Molecules 2018, 23(9), 2361; https://doi.org/10.3390/molecules23092361 (registering DOI)

Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert

1
Departamento de Química y Farmacia, Facultad de Ciencias, Universidad Católica del Norte, Angamos 0610, Antofagasta 1240000, Chile
2
Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, Valdivia 5090000, Chile
3
Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile
4
Laboratorio de Productos Naturales, Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Casilla 170, Antofagasta 1240000, Chile
5
Departamento de Ciencias Químicas, Universidad Andres Bello, Campus Viña del Mar, Quillota 980, Viña del Mar 2520000, Chile
6
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago 8320198, Chile
*
Authors to whom correspondence should be addressed.
Received: 7 August 2018 / Revised: 7 September 2018 / Accepted: 14 September 2018 / Published: 15 September 2018
Full-Text   |   PDF [2095 KB, uploaded 15 September 2018]   |  

Abstract

Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant. View Full-Text
Keywords: clerodanes; tremetones; gastroprotective; LC-MS/MS; gastric ulcer; endemic plants clerodanes; tremetones; gastroprotective; LC-MS/MS; gastric ulcer; endemic plants
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Ardiles, A.; Barrientos, R.; Simirgiotis, M.J.; Bórquez, J.; Sepúlveda, B.; Areche, C. Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert. Molecules 2018, 23, 2361.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top