Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert
AbstractForty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant. View Full-Text
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Ardiles, A.; Barrientos, R.; Simirgiotis, M.J.; Bórquez, J.; Sepúlveda, B.; Areche, C. Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert. Molecules 2018, 23, 2361.
Ardiles A, Barrientos R, Simirgiotis MJ, Bórquez J, Sepúlveda B, Areche C. Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert. Molecules. 2018; 23(9):2361.Chicago/Turabian Style
Ardiles, Alejandro; Barrientos, Ruth; Simirgiotis, Mario J.; Bórquez, Jorge; Sepúlveda, Beatriz; Areche, Carlos. 2018. "Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert." Molecules 23, no. 9: 2361.
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