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Molecules 2018, 23(9), 2097; https://doi.org/10.3390/molecules23092097

The α-Cyclodextrin/Moringin Complex: A New Promising Antimicrobial Agent against Staphylococcus aureus

1
IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
2
Consiglio per la Ricerca in Agricoltura e l’Analisi dell’Economia Agraria, Centro di Ricerca Agricoltura e Ambiente (CREA-AA), Via di Corticella 133, 40128 Bologna, Italy
3
Institute of Organic and Analytical Chemistry (ICOA), Université d’Orléans et the French National Center for Scientific Research (CNRS), Pôle de chimie, rue de Chartres, BP 6759, 45067 Orléans, CEDEX 2, France
*
Author to whom correspondence should be addressed.
Received: 23 July 2018 / Revised: 18 August 2018 / Accepted: 18 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Natural Active Agents Against Bacteria, Fungi and Parasites)
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Abstract

Antimicrobial resistance is one of the major clinical concerns, making the discovery of new antimicrobial drugs desirable. Moringin (MOR), the major isothiocyanate produced from Moringa oleifera seeds, could represent an alternative therapeutic strategy to commonly used antibiotics. The aim of our study was to investigate the antimicrobial effect of MOR conjugated with α-cyclodextrin (MOR/α-CD), a complex with an improved solubility and stability in aqueous solutions. Our data demonstrated that MOR/α-CD was able to exert antimicrobial activity against the S. aureus reference strains (ATCC 25923, ATCC 6538, and ATCC BAA-977). Moreover, MOR/α-CD showed bacteriostatic effects (MIC = minimum inhibitory concentration = 0.5 mg/mL) and bactericidal properties (MBC = minimum bactericidal concentration = 1 mg/mL) against the overall assessed strains. In addition, MOR/α-CD showed bactericidal activity against the S. aureus strain ATCC BAA-977 after treatment with erythromycin (Ery), which induced clindamycin-resistance on the erm (A) gene. This evidence led us to assume that MOR/α-CD could be a promising antimicrobial agent against strains with the clindamycin-resistant phenotype (CC-resistant). View Full-Text
Keywords: moringin; Moringa oleifera; Staphylococcus aureus (S. aureus); minimum inhibitory concentration (MIC); minimum bactericidal concentration (MBC); time-kill curve; clindamycin-resistant S. aureus strain (CC-resistant) moringin; Moringa oleifera; Staphylococcus aureus (S. aureus); minimum inhibitory concentration (MIC); minimum bactericidal concentration (MBC); time-kill curve; clindamycin-resistant S. aureus strain (CC-resistant)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Romeo, L.; Lanza Cariccio, V.; Iori, R.; Rollin, P.; Bramanti, P.; Mazzon, E. The α-Cyclodextrin/Moringin Complex: A New Promising Antimicrobial Agent against Staphylococcus aureus. Molecules 2018, 23, 2097.

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