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Molecules 2018, 23(8), 2082; https://doi.org/10.3390/molecules23082082

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

1
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
2
Jiangsu Key Lab for the Chemistry & Utilization for Agricultural and Forest Biomass, Nanjing Forestry University, Nanjing 210037, China
*
Author to whom correspondence should be addressed.
Received: 27 July 2018 / Revised: 9 August 2018 / Accepted: 14 August 2018 / Published: 20 August 2018
(This article belongs to the Special Issue Emerging Trends in Nanocelluloses)
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Abstract

Cellulose has been widely used in the biomedical field. In this study, novel cellulose aerogels were firstly prepared in a NaOH-based solvent system by a facile casting method. Then amoxicillin was successfully loaded into cellulose aerogels with different loadings. The morphology and structure of the cellulose aerogels were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The drug release and antibacterial activities were also evaluated. The drug release results showed that cellulose aerogels have controlled amoxicillin release performance. In vitro antibacterial assay demonstrated that the cellulose aerogels exhibited excellent antibacterial activity with the amoxicillin dose-dependent activity. Therefore, the developed cellulose aerogels display controlled release behavior and efficient antibacterial performance, thus confirming their potential for biomedical applications. View Full-Text
Keywords: cellulose; amoxicillin; controlled release; antibacterial cellulose; amoxicillin; controlled release; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ye, S.; He, S.; Su, C.; Jiang, L.; Wen, Y.; Zhu, Z.; Shao, W. Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels. Molecules 2018, 23, 2082.

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