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Molecules 2018, 23(8), 1991; https://doi.org/10.3390/molecules23081991

Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl4-Induced Hepatic Fibrosis Animal Model

1
Department of Pathology, College of Medicine, Catholic University of Daegu, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu 42472, Korea
2
Department of Pathology, Dongguk University School of Medicine, Gyeongju 38066, Korea
3
School of Biomedical Sciences, Charles Sturt University, Panorama Avenue, Bathurst, NSW 2795, Australia
*
Author to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 8 August 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
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Abstract

Hepatic fibrosis is the wound-healing process of chronic hepatic disease that leads to the end-stage of hepatocellular carcinoma and demolition of hepatic structures. Epithelial–mesenchymal transition (EMT) has been identified to phenotypic conversion of the epithelium to mesenchymal phenotype that occurred during fibrosis. Smad decoy oligodeoxynucleotide (ODN) is a synthetic DNA fragment containing a complementary sequence of Smad transcription factor. Thus, this study evaluated the antifibrotic effects of Smad decoy ODN on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice. As shown in histological results, CCl4 treatment triggered hepatic fibrosis and increased Smad expression. On the contrary, Smad decoy ODN administration suppressed fibrogenesis and EMT process. The expression of Smad signaling and EMT-associated protein was markedly decreased in Smad decoy ODN-treated mice compared with CCl4-injured mice. In conclusion, these data indicate the practicability of Smad decoy ODN administration for preventing hepatic fibrosis and EMT processes. View Full-Text
Keywords: liver fibrosis; Smad; decoy; oligodeoxynucleotide; CCl4 liver fibrosis; Smad; decoy; oligodeoxynucleotide; CCl4
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Gwon, M.-G.; Kim, J.-Y.; An, H.-J.; Kim, W.-H.; Gu, H.; Kim, M.-K.; Pak, S.C.; Park, K.-K. Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl4-Induced Hepatic Fibrosis Animal Model. Molecules 2018, 23, 1991.

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