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Molecules 2018, 23(8), 1982; https://doi.org/10.3390/molecules23081982

New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity

1
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China
2
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, 99 South Road of Longkun Road, Haikou 571158, China
3
Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
4
College of Marine Sciences, South China Agricultural University, 483 Wushan Road, Guangzhou 510642, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Muhammad Ilias and Charles L. Cantrell
Received: 15 July 2018 / Revised: 5 August 2018 / Accepted: 8 August 2018 / Published: 9 August 2018
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Abstract

Five new chromone derivatives, arthones A–E (15), together with eight known biogenetically related cometabolites (613), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC50 values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM. View Full-Text
Keywords: Arthrinium sp.; chromone; polyketide; antioxidant activity Arthrinium sp.; chromone; polyketide; antioxidant activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bao, J.; He, F.; Yu, J.-H.; Zhai, H.; Cheng, Z.-Q.; Jiang, C.-S.; Zhang, Y.; Zhang, Y.; Zhang, X.; Chen, G.; Zhang, H. New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity. Molecules 2018, 23, 1982.

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