Next Article in Journal
Surface Response Methodology-Based Mixture Design to Study the Influence of Polyol Blend Composition on Polyurethanes’ Properties
Previous Article in Journal
Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα
Article Menu

Export Article

Open AccessReview
Molecules 2018, 23(8), 1941; https://doi.org/10.3390/molecules23081941

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

1
Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana SI-1000, Slovenia
2
Jožef Stefan International Postgraduate School, Ljubljana SI-1000, Slovenia
*
Author to whom correspondence should be addressed.
Received: 6 July 2018 / Revised: 31 July 2018 / Accepted: 1 August 2018 / Published: 3 August 2018
View Full-Text   |   Download PDF [2142 KB, uploaded 3 August 2018]   |  

Abstract

Cancer cells possess remarkable abilities to adapt to adverse environmental conditions. Their survival during severe nutrient and oxidative stress depends on their capacity to acquire extracellular lipids and the plasticity of their mechanisms for intracellular lipid synthesis, mobilisation, and recycling. Lipid droplets, cytosolic fat storage organelles present in most cells from yeast to men, are emerging as major regulators of lipid metabolism, trafficking, and signalling in various cells and tissues exposed to stress. Their biogenesis is induced by nutrient and oxidative stress and they accumulate in various cancers. Lipid droplets act as switches that coordinate lipid trafficking and consumption for different purposes in the cell, such as energy production, protection against oxidative stress or membrane biogenesis during rapid cell growth. They sequester toxic lipids, such as fatty acids, cholesterol and ceramides, thereby preventing lipotoxic cell damage and engage in a complex relationship with autophagy. Here, we focus on the emerging mechanisms of stress-induced lipid droplet biogenesis; their roles during nutrient, lipotoxic, and oxidative stress; and the relationship between lipid droplets and autophagy. The recently discovered principles of lipid droplet biology can improve our understanding of the mechanisms that govern cancer cell adaptability and resilience to stress. View Full-Text
Keywords: lipid droplets; fatty acids; autophagy; lipophagy; cancer; oxidative stress; nutrient stress; lipotoxicity; lipase; phospholipase lipid droplets; fatty acids; autophagy; lipophagy; cancer; oxidative stress; nutrient stress; lipotoxicity; lipase; phospholipase
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Petan, T.; Jarc, E.; Jusović, M. Lipid Droplets in Cancer: Guardians of Fat in a Stressful World. Molecules 2018, 23, 1941.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top