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Molecules 2018, 23(7), 1643; https://doi.org/10.3390/molecules23071643

Improving Hydrophilicity and Inducing Bone-Like Apatite Formation on PPBES by Polydopamine Coating for Biomedical Application

1,2
,
2
,
1,2,3
,
1,2,* , 2
and
1,2,3,*
1
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
2
Department of Polymer Science & Engineering, Dalian University of Technology, Dalian 116024, China
3
Liaoning Province Engineering Research Centre of High Performance Resins, Dalian 116024, China
*
Authors to whom correspondence should be addressed.
Received: 21 June 2018 / Revised: 29 June 2018 / Accepted: 29 June 2018 / Published: 5 July 2018
(This article belongs to the Special Issue Amphiphilic Polymers: Self-Assembly and Applications)
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Abstract

Copoly(phthalazinone biphenyl ether sulfone) (PPBES) as a commercially available polyarylether is a promising orthopaedic implant material because its mechanical properties are similar to bone. However, the bioinert surface of polyarylether causes some clinical problems after implantation, which limits its application as an implant material. In this study, the surface of PPBES was modified by a biomineralization method of polydopamine-assisted hydroxyapatite formation (pHAF) to enhance its cytocompatibility. Polydopamine (PDA) coating, inspired by the adhesion mechanism of mussels, can readily endow PPBES with high hydrophilicity and the ability to integrate via the bone-like apatite coating. PPBES and PDA-coated PPBES were evaluated by scanning electronic microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and contact angle measurement. The water contact angles were reduced significantly after coating with PDA. PDA was successfully synthesized on PPBES and more PDA was obtained by increasing the temperature. Bone-like apatite on PPBES (apatite-coated PPBES) was confirmed by SEM and transmission electron microscopy (TEM). The cytotoxicity of pristine PPBES and apatite-coated PPBES were characterized by culturing of NIH-3T3 cells. Bone-like apatite synthesized by pHAF could further enhance cytocompatibility in vitro. This study provides a promising alternative for biofunctionalized PPBES with improved cytocompatibility for bone implant application. View Full-Text
Keywords: polydopamine; bone-like apatite; phthalazinone; PPBES; coating; cytocompatibility polydopamine; bone-like apatite; phthalazinone; PPBES; coating; cytocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Liu, C.; Li, Y.; Wang, J.; Liu, C.; Liu, W.; Jian, X. Improving Hydrophilicity and Inducing Bone-Like Apatite Formation on PPBES by Polydopamine Coating for Biomedical Application. Molecules 2018, 23, 1643.

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