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Molecules 2018, 23(7), 1622; https://doi.org/10.3390/molecules23071622

Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease

1,2
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1,2,3
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1
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1
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1,2,* and 1,2,*
1
Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, Shanghai 201203, China
2
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, Shanghai 201203, China
3
Shaanxi Academy of Traditional Chinese Medicine, Xi’an 710003, Shaanxi, China
*
Authors to whom correspondence should be addressed.
Received: 2 June 2018 / Revised: 25 June 2018 / Accepted: 28 June 2018 / Published: 4 July 2018
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [377 KB, uploaded 4 July 2018]   |  

Abstract

Inflammatory bowel disease (IBD) is a common disease characterized by chronic inflammation in gastrointestinal tracts, which is primarily treated by administering anti-inflammatory and immunosuppressive drugs that inhibit the burden of intestinal inflammation and improve disease-related symptoms. However, the established therapeutic strategy has limited therapeutic efficacy and adverse drug reactions. Therefore, new disease-targeting drug-delivery strategies to develop more effective treatments are urgent. This review provides an overview of the drug-targeting strategies that can be used to treat IBD, and our recent attempts on the colon-specific delivery system (Pae-SME-CSC) with a paeonol-loaded self-microemulsion (Pae-SMEDDS) are introduced. View Full-Text
Keywords: targeted drug-delivery strategies; treatment; inflammatory bowel disease targeted drug-delivery strategies; treatment; inflammatory bowel disease
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Guo, Y.; Zong, S.; Pu, Y.; Xu, B.; Zhang, T.; Wang, B. Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease. Molecules 2018, 23, 1622.

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