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Molecules 2018, 23(7), 1618; https://doi.org/10.3390/molecules23071618

Continuous Flow Alcoholysis of Dialkyl H-Phosphonates with Aliphatic Alcohols

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary
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Received: 14 June 2018 / Revised: 29 June 2018 / Accepted: 1 July 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Organophosphorus Chemistry 2018)
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Abstract

The continuous flow alcoholysis of dialkyl H-phosphonates by aliphatic alcohols in the absence of a catalyst was elaborated using a microwave (MW) reactor equipped with a flow cell. By the precise control of the reaction conditions, the synthesis could be fine-tuned towards dialkyl H-phosphonates with two different and with two identical alkyl groups. In contrast to the “traditional” batch alcoholysis, flow approaches required shorter reaction times, and the products became available at a larger scale. View Full-Text
Keywords: dialkyl H-phosphonates; alcoholysis; transesterification; microwave; continuous flow reactor dialkyl H-phosphonates; alcoholysis; transesterification; microwave; continuous flow reactor
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Bálint, E.; Tajti, Á.; Tóth, N.; Keglevich, G. Continuous Flow Alcoholysis of Dialkyl H-Phosphonates with Aliphatic Alcohols. Molecules 2018, 23, 1618.

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