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Molecules 2018, 23(7), 1563; https://doi.org/10.3390/molecules23071563

Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation

1
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
2
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
3
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
*
Authors to whom correspondence should be addressed.
Received: 23 May 2018 / Revised: 22 June 2018 / Accepted: 26 June 2018 / Published: 28 June 2018
(This article belongs to the Special Issue Advances in Natural Polysaccharides Research)
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Abstract

Polysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-κB in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent. View Full-Text
Keywords: astragalus polysaccharide; quercetin; cytokines; macrophage; foods astragalus polysaccharide; quercetin; cytokines; macrophage; foods
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Z.-P.; Liu, H.-B.; Zhang, Q.-W.; Li, L.-F.; Bao, W.-R.; Ma, D.-L.; Leung, C.-H.; Bian, Z.-X.; Lu, A.-P.; Han, Q.-B. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. Molecules 2018, 23, 1563.

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