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Molecules 2018, 23(6), 1419; https://doi.org/10.3390/molecules23061419

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

1
Department of Health & Biomedical Sciences, School of Life Science and Bioengineering, The Nelson Mandela Africa Institute of Science and Technology, P.O. Box 447, Arusha, Tanzania
2
Department of Chemistry, Faculty of Natural and Applied Sciences, St. John’s University of Tanzania P.O. Box 47, Dodoma, Tanzania
3
Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
4
Office of the Vice Chancellor, University of Dodoma, P.O. Box 259, Dodoma, Tanzania
All authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 April 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 12 June 2018
(This article belongs to the Special Issue Dendrimers in Medicine)
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Abstract

Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the therapeutic potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers in pre-clinical and clinical settings. Besides formulation strategies, factors such as pH, PAMAM dendrimer generation, PAMAM dendrimer concentration, nature of the PAMAM core, special ligand and surface modifications of PAMAM dendrimer have an influence on drug solubility and other recommendable pharmacological properties. This review, therefore, compiles the recently reported applications of PAMAM dendrimers in pre-clinical and clinical uses as enhancers of solubility and other desirable properties such as sustained and controlled release, bioavailability, bio-distribution, toxicity reduction or enhancement, and targeted delivery of small molecules with emphasis on cancer treatment. View Full-Text
Keywords: PAMAM dendrimer; solubility enhancement; drug delivery; small molecules PAMAM dendrimer; solubility enhancement; drug delivery; small molecules
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Shadrack, D.M.; Swai, H.S.; Munissi, J.J.E.; Mubofu, E.B.; Nyandoro, S.S. Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies. Molecules 2018, 23, 1419.

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