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Molecules 2018, 23(5), 994; https://doi.org/10.3390/molecules23050994

To Decipher the Mycoplasma hominis Proteins Targeting into the Endoplasmic Reticulum and Their Implications in Prostate Cancer Etiology Using Next-Generation Sequencing Data

1
Research Center, College of Computer and Information Science, King Saud University, Riyadh 11451, Saudi Arabia
2
Nanomedicine & Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Bioscience, Shri Ram Group of College (SRGC), Muzaffarnagar 251002, UP, India
4
Department of Pharmacology, College of Medicine, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh 11451, Saudi Arabia
5
Phase I-Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, “Centre for Oncological Research (CORE)”, 2650 Edegem, Belgium
6
Computer Science Department, College of Computer and Information Sciences, King Saud University, Riyadh 11451, Saudi Arabia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Xiangxiang Zeng, Alfonso Rodríguez-Patón and Quan Zou
Received: 7 March 2018 / Revised: 16 April 2018 / Accepted: 18 April 2018 / Published: 24 April 2018
(This article belongs to the Special Issue Molecular Computing and Bioinformatics)
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Abstract

Cancer was initially considered a genetic disease. However, recent studies have revealed the connection between bacterial infections and growth of different types of cancer. The enteroinvasive strain of Mycoplasma hominis alters the normal behavior of host cells that may result in the growth of prostate cancer. The role of M. hominis in the growth and development of prostate cancer still remains unclear. The infection may regulate several factors that influence prostate cancer growth in susceptible individuals. The aim of this study was to predict M. hominis proteins targeted into the endoplasmic reticulum (ER) of the host cell, and their potential role in the induction of prostate cancer. From the whole proteome of M. hominis, 19 proteins were predicted to be targeted into the ER of host cells. The results of our study predict that several proteins of M. hominis may be targeted to the host cell ER, and possibly alter the normal pattern of protein folding. These predicted proteins can modify the normal function of the host cell. Thus, the intercellular infection of M. hominis in host cells may serve as a potential factor in prostate cancer etiology. View Full-Text
Keywords: prostate cancer; Mycoplasma hominis; endoplasmic reticulum; systems biology; protein targeting prostate cancer; Mycoplasma hominis; endoplasmic reticulum; systems biology; protein targeting
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Zakariah, M.; Khan, S.; Chaudhary, A.A.; Rolfo, C.; Ben Ismail, M.M.; Alotaibi, Y.A. To Decipher the Mycoplasma hominis Proteins Targeting into the Endoplasmic Reticulum and Their Implications in Prostate Cancer Etiology Using Next-Generation Sequencing Data. Molecules 2018, 23, 994.

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