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Molecules 2018, 23(5), 1208; https://doi.org/10.3390/molecules23051208

Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential

1
Advanced Center of Chronic Diseases (ACCDiS), Universidad de Chile. Santos Dumont 964, Independencia, Santiago 8380494, Chile
2
Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494, Chile
3
Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494, Chile
4
Cellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago 8380453, Chile
5
Center for studies on Exercise, Metabolism and Cancer (CEMC), Universidad de Chile, Av. Independencia 1027, Independencia, Santiago 8380453, Chile
6
Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Av. Republica 275, Santiago 8370251, Chile
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 13 April 2018 / Revised: 13 May 2018 / Accepted: 14 May 2018 / Published: 18 May 2018
(This article belongs to the Collection Nanomedicine)
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Abstract

Here we report the incorporation of gold nanostructures (nanospheres or nanorods, functionalized with carboxylate-end PEG) and curcumin oil-in-water (O/W) nanoemulsions (CurNem) into alginate microgels using the dripping technique. While gold nanostructures are promising nanomaterials for photothermal therapy applications, CurNem possess important pharmacological activities as reported here. In this sense, we evaluated the effect of CurNem on cell viability of both cancerous and non-cancerous cell lines (AGS and HEK293T, respectively), demonstrating preferential toxicity in cancer cells and safety for the non-cancerous cells. After incorporating gold nanostructures and CurNem together into the microgels, microstructures with diameters of 220 and 540 µm were obtained. When stimulating microgels with a laser, the plasmon effect promoted a significant rise in the temperature of the medium; the temperature increase was higher for those containing gold nanorods (11–12 °C) than nanospheres (1–2 °C). Interestingly, the incorporation of both nanosystems in the microgels maintains the photothermal properties of the gold nanostructures unmodified and retains with high efficiency the curcumin nanocarriers. We conclude that these results will be of interest to design hydrogel formulations with therapeutic applications. View Full-Text
Keywords: gold nanoparticles; gold nanorods; nanoemulsions; curcumin; microgels; encapsulation gold nanoparticles; gold nanorods; nanoemulsions; curcumin; microgels; encapsulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Inostroza-Riquelme, M.; Vivanco, A.; Lara, P.; Guerrero, S.; Salas-Huenuleo, E.; Chamorro, A.; Leyton, L.; Bolaños, K.; Araya, E.; Quest, A.F.G.; Kogan, M.J.; Oyarzun-Ampuero, F. Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential. Molecules 2018, 23, 1208.

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